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Table 4 Association of H. pylori and its virulence genes vacA s1m1, cagA, babA2 with gastric ulcer and gastric cancer

From: Helicobacter pylori vacA s1m1 genotype but not cagA or babA2 increase the risk of ulcer and gastric cancer in patients from Southern Mexico

  Diagnosis
Gastric ulcer Gastric cancer
OR (CI 95%) p value ORa (CI 95%) p value
H. pylori
 Negative 1.0b   1.0b  
 Positive 1.07 (0.71–1.61) 0.728 2.08 (1.05–4.13) 0.035
vacA
 s2m2 1.0b   1.0b  
 s1m1 2.02 (1.12–3.62) 0.019 6.58 (2.15–20.08) 0.001
cagA
 Negative 1.0b   1.0b  
 Positive 1.02 (0.56–1.86) 0.934 1.22 (0.47–3.17) 0.676
babA2
 Negative 1.0b   1.0b  
 Positive 0.97 (0.50–1.85) 0.927 2.50 (0.99–6.32) 0.052
Genotype
 s2m2/cagA 1.0b   1.0b  
 s2m2/cagA+ 2.5 (0.33–18.6) 0.374
 s1m1/cagA 4.3 (1.02–18.2) 0.047 1.8 (0.15–22.1) 0.639
 s1m1/cagA+ 1.5 (0.40–5.5) 0.550 2.1 (0.25–16.8) 0.502
  1. aOR adjusted for age and overcrowding
  2. bReference group: chronic gastritis