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Table 7 Systemic cytokines/chemokines measured in serum of piglets during course of infection using FMIA

From: Comparison of clinical and immunological findings in gnotobiotic piglets infected with Escherichia coli O104:H4 outbreak strain and EHEC O157:H7

  Negative E. coli O104:H4 E. coli O157:H7
Median (min–max) Median (min–max) Median (min–max)
Time range: T1, n = 3 T2; n = 3 T3; n = 2 T1; n = 5 T2; n = 6 T3; n = 5 T1; n = 3 T2; n = 4 T3; n = 1
IL1β pg/ml 6.3 (6.3–14.6) 4.7 (3.3–6.5) 5.6 (5.6–5.7) 5.6 (5.0–8.1) 5.6 (4.6–8.4) 5.9 (3.9–7.0) 7.7 (6.7–8.4) 7.5 (5.5–8.9) 8.8
IL12 pg/ml 279.7 (195.0–413.9) 104.0 (101.4–126.9) 2263.4 (106.5–4420.4) 194.9 (152.8–10856.4) 165.9 (91.3–714.8) 91.3 (42.4–139.8) 134.7 (126.9–243.1) 197.1 (93.9–6247.2) 352.5
CCL2 pg/ml 807.1 (730.7–3973.4) 1529.7 (840.6–2935.0) 2550.6 (1751.2–3350.0) 536.4 (251.5–1176.4) 1372.8 (570.1–3598.0) 1917.8 (826.3–4011.7) 603.1 (441.9–672.1) 453.9 (365.4–513.5) 677.3
IFNγ pg/ml 2.8 (0.0–13.6) 0.0 (0.0–16.3) 4.0 (0.0–8.0) 0.0 (0.0–4.2) 38.7 (2.8–582.8) 5.5 (0.0–63.6) 0.0 (0.0–4.2) 48.3 (46.2–98.3) 30.5
IL10 pg/ml 49.4 (45.0–51.5) 11.2 (9.2–15.4) 17.1 (16.7–17.5) 29.5 (22.0–33.1) 20.1 (18.8–30.0) 11.5 (9.8–17.5) 22.7 (22.5–26.2) 19.4 (14.6–31.4) 26.7
  1. T1 timerange 1, preinfectionem, T2 timerange 2, day 4–day 6 p.i., T3 timerange, day 7–day 12 p.i.