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Table 1 Minimum inhibitory concentrations to various antibiotics for MAP strains used in this study under aerobic versus anaerobic conditions

From: Anaerobic adaptation of Mycobacterium avium subspecies paratuberculosis in vitro: similarities to M. tuberculosis and differential susceptibility to antibiotics

MAP strain Condition Test ranges and MICs (µg/ml)
RIF RFX AMI CIP CLR EMB GEN MET MES SAL
ATCC 19698 Aerobic 2 0.5 2 2 0.5 4 1 >12.5 >25 >25
Anaerobic >8 >8 >16 >8 >8 >16 >16 12.5 NT NT
B-1 Aerobic 1 1 4 2 1 8 2 >12.5 >25 >25
Anaerobic >8 >8 >16 >8 >8 >16 >16 12.5 NT NT
B-2 Aerobic 0.25 0.25 2 1 0.125 2 2 >12.5 >25 >25
Anaerobic >8 >8 >16 >8 >8 >16 >16 12.5 NT NT
B-3 Aerobic 2 0.5 4 2 2 16 2 >12.5 >25 >25
Anaerobic >8 >8 >16 >8 >8 >16 >16 12.5 NT NT
ATCC 43544 Aerobic 4 1 8 1 1 8 4 >12.5 >25 >25
Anaerobic >8 >8 >16 >8 >8 >16 >16 12.5 NT NT
  1. The concentrations shown are the highest tested for each antibiotic in the anaerobic model
  2. M. bovis BCG ATCC 35734 (Pasteur) was used as a control for the anaerobic model as previously described [45]. Aerobic MICs for BCG were <0.1 for isoniazid and ≤0.06 for rifampin. Neither drug significantly inhibited growth of BCG in the anaerobic model at concentrations above (INH >0.4; RIF >0.1) that observed under aerobic conditions
  3. RIF rifampin, RFX rifaximin, AMI amikacin, CIP ciprofloxacin, CLR clarithromycin, EMB ethambutol, GEN gentamicin, MET metronidazole, MES mesalamine, SAL salicilin, NT not tested