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Table 1 Minimum inhibitory concentrations to various antibiotics for MAP strains used in this study under aerobic versus anaerobic conditions

From: Anaerobic adaptation of Mycobacterium avium subspecies paratuberculosis in vitro: similarities to M. tuberculosis and differential susceptibility to antibiotics

MAP strain

Condition

Test ranges and MICs (µg/ml)

RIF

RFX

AMI

CIP

CLR

EMB

GEN

MET

MES

SAL

ATCC 19698

Aerobic

2

0.5

2

2

0.5

4

1

>12.5

>25

>25

Anaerobic

>8

>8

>16

>8

>8

>16

>16

12.5

NT

NT

B-1

Aerobic

1

1

4

2

1

8

2

>12.5

>25

>25

Anaerobic

>8

>8

>16

>8

>8

>16

>16

12.5

NT

NT

B-2

Aerobic

0.25

0.25

2

1

0.125

2

2

>12.5

>25

>25

Anaerobic

>8

>8

>16

>8

>8

>16

>16

12.5

NT

NT

B-3

Aerobic

2

0.5

4

2

2

16

2

>12.5

>25

>25

Anaerobic

>8

>8

>16

>8

>8

>16

>16

12.5

NT

NT

ATCC 43544

Aerobic

4

1

8

1

1

8

4

>12.5

>25

>25

Anaerobic

>8

>8

>16

>8

>8

>16

>16

12.5

NT

NT

  1. The concentrations shown are the highest tested for each antibiotic in the anaerobic model
  2. M. bovis BCG ATCC 35734 (Pasteur) was used as a control for the anaerobic model as previously described [45]. Aerobic MICs for BCG were <0.1 for isoniazid and ≤0.06 for rifampin. Neither drug significantly inhibited growth of BCG in the anaerobic model at concentrations above (INH >0.4; RIF >0.1) that observed under aerobic conditions
  3. RIF rifampin, RFX rifaximin, AMI amikacin, CIP ciprofloxacin, CLR clarithromycin, EMB ethambutol, GEN gentamicin, MET metronidazole, MES mesalamine, SAL salicilin, NT not tested
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Gut Pathogens

ISSN: 1757-4749