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Fig. 4 | Gut Pathogens

Fig. 4

From: Toll-like receptor-4 differentially mediates intestinal and extra-intestinal immune responses upon multi-drug resistant Pseudomonas aeruginosa association of IL10−/− mice with chronic colitis

Fig. 4

Clinical conditions in IL10−/− mice lacking TLR4 following peroral association with multi-drug resistant P. aeruginosa. Conventionally colonized IL10 deficient (WT IL10−/−; closed circles) and TLR4 deficient IL10−/− mice (TLR4−/− × IL10−/−; closed triangles, black bar) were perorally challenged with a clinical multi-drug resistant P. aeruginosa (PA) strain at day (d) 0. a Clinical symptoms (applying a standardized clinical scoring system) and b fecal blood-positivity rates were surveyed at day 14 p.i. Naive (N) mice served as negative controls (white bar). Numbers of mice displaying clinical symptoms including blood-positive feces out of the total numbers of analyzed animals (in parentheses), median (black bars; a), blood-positivity rates ± standard deviations (in %; b) and significance levels (p values) determined by the Mann–Whitney U test are indicated. Data shown were pooled from three independent experiments

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Gut Pathogens

ISSN: 1757-4749