Gut microbiome associated with chemotherapy-induced diarrhea from the CapeOX regimen as adjuvant chemotherapy in resected stage III colorectal cancer

Table 2 Gut microbial richness and diversity associated with chemotherapy-induced diarrhea of the CapeOX regimen in CRC

Group	n	Coverage	OTU	Ace	Chao	Shannon	Simpson
Experimental group	4	0.9994 ± 0.0008	119.75 ± 53.44	159.50 ± 100.09	150.75 ± 77.58	2.21 ± 0.47	0.21 ± 0.08
Control group	13	0.9985 ± 0.0012	273.38 ± 93.68	336.31 ± 117.73	332.46 ± 113.34	3.36 ± 0.59	0.09 ± 0.07
t value	–	–	− 3.08	− 2.70	− 2.97	− 3.54	2.30
p value	–	–	0.008	0.016	0.010	0.003	0.009

Mothur software (http://www.mothur.org/wiki/Main_Page) was used to analyze the microbial diversity. Operational taxonomic units (OTU), as the artificial classification unit, was used to estimate the number of species in each sample, and the similarity threshold was 97%. The alpha diversity analysis was shown in Additional file 1

ISSN: 1757-4749