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Table 1 Involvement of miRNAs in host viral interaction

From: Exosomal miRNAs in hepatitis B virus related liver disease: a new hope for biomarker

 Mode of actionmiRNAValidation statusMajor findingsReferences
miRNAs that facilitate viral replicationHost miRNA directly promote viral replicationmiR-15bExperimentally validatedPromotes HBV replication by aiding HBV enhancer I activity HNF-1α[49]
miR-501Experimentally validatedActivates HBV replication by repressing HBx-interacting protein (HBXIP)[50]
miR-1Experimentally validatedEnhances HBV core promoter activity by promoting farnesoid X receptor α expression[51]
miRs-372/373Experimentally validatedStimulated the production of HBV proteins and HBV core-associated DNA by targeting nuclear factor I/B[52]
miRNAs that directly inhibit viral replicationmiRNAs with target sequences in the viral genomelet-7,miR-196b, miR-433, miR-511Computational analysisTargets polymerase and surface genes[53]
miR-205Computational analysisTargets HBX[53]
miR-345Computational analysisTargets pre-core genes[53]
miR-122Experimentally validatedTargets mRNA coding region for viral polymerase & core protein[54]
miR-199a-3pExperimentally validatedTargets HBsAg coding region[55]
miR-210Experimentally validatedTargets p Targets re-S1 region[51]
miR-125a-5pExperimentally validatedInteracts with the HBV surface antigen[56]
miR-15aExperimentally validatedTargets HBx transcript[57]
miR-20a, miR-92a-1, miR-16-1Experimentally validatedTargets HBV transcripts[58]
miR-205Experimentally validatedTargets HBx gene[59]
miRNAs that indirectly inhibit viral replicationIndirectly regulates viral replication/transcription by targeting other host factors linked with viral replicationmiR-122Experimentally validatedPromotes viral replication by targeted inhibition of heme oxygenase-1[60]
miR-122Experimentally validatedTargets CCNG1 and NDRG3 to inhibit viral replication[61]
miR-29cExperimentally validatedSuppresses HBV replication by targeting TNFAIP3[62]
miR-125bExperimentally validatedInhibits HBV DNA intermediates and the secretion of HBsAg and HBeAg by targeted repression of SCNN1Α[63]
miR-141Experimentally validatedRepress HBV replication by targeting of PPARα[64]
miR-155Experimentally validatedRepress HBV replication by targeting of C/EBP-β[65]
miR-130aExperimentally validatedRepresses HBV replication by targeting HBV transcription enhancers PGC1α and PPAR[66]