Table 3 Potentially causal genes for microbial traits detected by FOCUS
From: Transcriptome-wide association study identified candidate genes associated with gut microbiota
Gene | Chrom | Microbial trait | Reference panel | PIP | Identified by TWAS |
|---|---|---|---|---|---|
METTL15P1 | 3 | G_Faecalitalea_RNT | Sigmoid colon | 0.821 | NO |
COL5A1-AS1 | 9 | G_Parasutterella_RNT | Sigmoid colon | 0.801 | NO |
RP1-257A7.4 | 6 | G_Veillonella_RNT | Sigmoid colon | 0.714 | NO |
HELLS | 10 | G_Streptococcus_RNT | Sigmoid colon | 0.685 | YES |
HELLS | 10 | F_Streptococcaceae_RNT | Sigmoid colon | 0.665 | YES |
FBXO27 | 19 | G_Aestuariispira_RNT | Sigmoid colon | 0.555 | NO |
NIPSNAP1 | 22 | G_Clostridium_sensu_RNT | Sigmoid colon | 0.537 | NO |
ANO7 | 2 | F_Erysipelotrichaceae_RNT | Sigmoid colon | 0.449 | YES |
FRRS1L | 9 | G_P_Firmicutes_RNT | Transverse colon | 0.826 | NO |
RP11-1277A3.2 | 5 | G_Intestinibacter_RNT | Transverse colon | 0.114 | NO |
STAG3L4 | 7 | G_Lachnospiraceae_RNT | Transverse colon | 0.171 | YES |
CPNE8 | 12 | G_F_Porphyromonadaceae_RNT | Transverse colon | 0.201 | NO |