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Fig. 2 | Gut Pathogens

Fig. 2

From: Myxopyronin B inhibits growth of a Fidaxomicin-resistant Clostridioides difficile isolate and interferes with toxin synthesis

Fig. 2

C. difficile toxin levels in the presence of sublethal concentrations of Rifaximin, Fidaxomicin and Myxopyronin B. Toxins A and B expression levels in C. difficile cells after stress with sublethal concentrations of Rifaximin (1.75 ng/ml; Rif), Fidaxomicin (6 ng/ml; Fid) and Myxopyronin B (500 ng/ml, MyxB) were quantified by western blot analysis. Values present the average signal intensities of toxin bands of three biological replicates in artificial units (a.u.) quantified by the “measure” tool of ImageJ. * indicates significant differences according to FDR adjusted t-testing using the R tool “rstatix”. DMSO DMSO-treated samples, Rif Rifaximin-treated samples, Fid Fidaxomicin-treated samples, MyxB Myxopyronin B-treated samples, a.u. artificial units

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Gut Pathogens

ISSN: 1757-4749