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Fig. 9 | Gut Pathogens

Fig. 9

From: Antimicrobial resistance patterns and genetic elements associated with the antibiotic resistance of Helicobacter pylori strains from Shanghai

Fig. 9

Cartoon model showing the putative genetic characteristics likely related to H. pylori resistance- or susceptibility- to MTZ, CLA and LEV at locus- and variant-levels. The intrinsic resistance or resistance-associated compensation related genetic features involves the variations in the genome-wide resistant gene-encoding proteins including antibiotic targets, translation-associated factors, transporters, OMPs, proteins probably related to biofilm formation, and other sporadic factors including lon protease with variations in linkage disequilibrium with many others, as well as the presence or absence of a porin, and an efflux pump transporter. In the underlying acquired resistance related genetic elements, the presence or absence of a virulence-associated factor belonging to ComB T4SS and a certain CRISPRs, as well as variations in several recombination required proteins, were demonstrated. Different colors of the genetic element names denote they are in relation to resistance or susceptibility of different antibiotics. Red (MTZ), gold (CLA), pink (LEV), orange (MTZ and CLA), blue (MTZ and LEV), brown (CLA and LEV)

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Gut Pathogens

ISSN: 1757-4749