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Table 4 AEs of IMT by subgroups

From: Adverse events of intestinal microbiota transplantation in randomized controlled trials: a systematic review and meta-analysis

subgroup

SAEs

CAEs

Number of studies

Event rate of IMT (%)

RR, 95% CI, over effect P-value

Subgroup differences

Number of studies

Event rate of IMT (%)

RR, 95%CI, over effect P-value

Subgroup differences

P-value

P-value

Type of stool sample

   

0.92

   

0.69

Fresh

6

1.72

RR = 1.46, 95%CI 0.26–8.25, P = 0.67

 

2

25.64

RR = 0.83, 95% CI 0.24–2.89, P = 0.76

 

Frozen

13

1.67

RR = 1.32, 95% CI 0.47–3.73, P = 0.60

 

5

72.65

RR = 1.06, 95% CI 0.90–1.26, P = 0.46

 

Delivery route

   

0.25

   

0.04

UGI

6

0.50

RR = 0.34, 95% CI 0.06–2.10, P = 0.25

 

3

84.00

RR = 1.15, 95% CI 0.93–1.43, P = 0.20

 

LGI

11

2.72

RR = 1.53, 95% CI 0.21–3.53, P = 0.45

 

3

34.45

RR = 0.86, 95% CI 0.68–1.10, P = 0.23

 

Both UGI and LGI

1

4.17

RR = 4.92, 95%CI 0.21–116.17, P = 0.32

 

0

 

Capsules

3

0

 

1

84.62

RR = 1.47, 95% CI 1.02–2.12, P = 0.04

 

Frequency

   

0.4

   

0.32

More than once

12

2.65

RR = 1.18, 95% CI 0.46–3.04, P = 0.74

 

4

81.25

RR = 1.13, 95% CI 0.93–1.37, P = 0.21

 

once

8

0.38

RR = 4.92, 95% CI 0.21–116.17, P = 0.32

 

3

16.87

RR = 0.85, 95% CI 0.49–1.45, P = 0.55

 

Dosage

   

0.48

   

0.86

Greater than 50 g

9

1.80

RR = 1.72, 95% CI 0.56–5.23, P = 0.34

 

2

29.63

RR = 0.88, 95% CI 0.20–3.80, P = 0.87

 

Less than 50 g

6

1.24

RR = 0.87, 95% CI 0.19–4.01, P = 0.86

 

2

80.95

RR = 1.0, 95% CI 0.84–1.20, P = 0.98

 
  1. IMT intestinal microbiota transplantation, SAEs serious adverse events, CAEs common adverse events, RR relative risk, CI confidence interval