Fig. 5

Map variable changes of GII.17 strains over time. a Side view of structure model of GII.17 clade A P domain dimer was shaded of grey. Residues changes between GII.17 clade A and GII.17 clade B (blue), between GII.17 clade B and GII.17 clade C (green), and between GII.17 clade C and GII.17 clade D (red). b Top views of the same model with (A). c Surface-exposed charge changes of residues of 293–300 in GII.17 clade D with alanine substitution (left side). Comparing with the wild type P domain structure model (right side), 293-300aa mutation in GII.17 clade D was likely to drove antigenic drift, losing the protrude motif