Table 6 Specific mutations associated with clarithromycin resistance development in UM171, UM626A1, and UM650B
Type | Locus tag (gene)/protein | Position | Type of variation | Bases change (amino acid change) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
UM171 | UM626A1 | UM650B | ||||||||||
S | B | R | S | B | R | S | B | R | ||||
SNV | K747_RS06360 (cag4)/transglycosylase SLT domain-containing protein | NC_021215.3:1292240 | Non-synonymous, exonic | G (R) | G>A (R47K) | G>A (R47K) | G (R) | G>A (R47K) | G>A (R47K) | G (R) | G>A (R47K) | G>A (R47K) |
NC_021215.3:1292491 | Non-synonymous, exonic | G (V) | G>A (V131M) | G>A (V131M) | G (V) | G>A (V131M) | G>A (V131M) | G (V) | G>A (V131M) | G>A (V131M) | ||
NC_021215.3:1292500 | Non-synonymous, exonic | A (I) | A>T (I134L) | A>T (I134L) | A (I) | A>T (I134L) | A>T (I134L) | A (I) | A>T (I134L) | A>T (I134L) | ||
K747_RS07265(rsmH)/16S rRNA (cytosine(1402)-N(4))-methyltransferase | NC_021215.3:1499504 | Non-synonymous, exonic | T (S) | T (S) | T>G (S244A) | T (S) | T>G (S244A) | T>G (S244A) | T (S) | T (S) | T>G (S244A) | |
NC_021215.3:1499056 | Non-synonymous, exonic | T (N) | T (N) | T>A (N94K) | T (N) | T>A (N94K) | T>A (N94K) | T (N) | T>A (N94K) | T>A (N94K) | ||
NC_021215.3:1499175 | Non-synonymous, exonic | A (D) | A (D) | A>G (D134G) | A (D) | A>G (D134G) | A>G (D134G) | A (D) | A>G (D134G) | A>G (D134G) | ||
NC_021215.3:1499345 | Non-synonymous, exonic | C (L) | C (L) | C>T (L191F) | C (L) | C>T (L191F) | C>T (L191F) | C (L) | C>T (L191F) | C>T (L191F) | ||
K747_RS06340/Sel1 repeat family protein | NC_021215.3:1289818 | Non-synonymous, exonic | C (D) | C>T (D39N) | C>T (D39N) | C (D) | C>T (D39N) | C>T (D39N) | C (D) | C>T (D39N) | C>T (D39N) | |
InDel | K747_RS06360 (cag4)/transglycosylase SLT domain-containing protein | NC_021215.3:1292229_1292232 | Frameshift deletion, exonic | AGTG (E) | – (E43fs) | AGTG (E) | AGTG (E) | – (E43fs) | – (E43fs) | AGTG (E) | – (E43fs) | – (E43fs) |
NC_021215.3:1292233_1292234 | Frameshift insertion, exonic | – (V) | ATAA (V45fs) | – (V) | – (V) | ATAA (V45fs) | ATAA (V45fs) | – (V) | ATAA (V45fs) | ATAA (V45fs) | ||
K747_RS06805/vacuolating cytotoxin domain-containing protein | NC_021215.3:1393215_1393219 | Frameshift deletion, exonic | ACTAG (L) | – (L2430fs) | ACTAG (L) | ACTAG (L) | – (L2430fs) | – (L2430fs) | ACTAG (L) | – (L2430fs) | – (L2430fs) | |
NC_021215.3:1393222_1393223 | Frameshift insertion, exonic | – (S) | CAAAC (S2433fs) | – (S) | – (S) | CAAAC (S2433fs) | CAAAC (S2433fs) | – (S) | CAAAC (S2433fs) | CAAAC (S2433fs) | ||