Fig. 1

Hypoxia increases mortality in Salmonella-infected mice. (A) The changes in the body weight in WT mice. (B) The changes in the body weight in MPO^−/− mice. Data were analyzed using repeated-measures ANOVA for body weight (n = 8/group; # p < 0.05 versus respectively with their baseline weight; & p < 0.05 versus CON group at the same time; *. p < 0.05 versus S group at the same time; + p < 0.05 versus M group at the same time; ^. p < 0.05 versus MS group at the same time). (C) Mice were continuously monitored for their survival (n = 8 /group). (D) neutrophilic granulocytes, (E) percentage of neutrophils, (F) red blood cell, and (G) hemoglobin were measured at 72 h. (H) Gene expression of VEGF was assessed via qPCR in colon. Values are expressed as mean ± SEM (n = 8 /group) and analyzed via one-way ANOVA with Tukey’s multiple comparisons test (*p < 0.05; **p < 0.01; ***p < 0.001)