Table 1 Amino acid substitutions in the ORF 1 genes of GII[P16] P-types associated with GII.3 and GII.4 capsids compared to GII[P16] reference stain (NC_039477.1)
From: Comprehensive full genome analysis of norovirus strains from eastern India, 2017–2021
ORF1 genes | Substitutions in GII[P16] ORF1 of GII.3 | Substitutions in GII[P16] ORF 1 of GII.4 | Common substitutions in GII[P16] ORF1 of both GII.3 and GII.4 |
|---|---|---|---|
NS1/2 (p48) | R43K, S53P, P57L, P60S, E78G, E79V, I185T, K280R, L302M, A323T | D51N, E52K, S53L, I68T, E76V, E79G, E86G, V112T, R191K, M248V, I259V, F260L, T266A, T294S, V311I | S49P, D51G, T169A |
NS3 (NTPase) | I17V, I138V, A309T | L9I, R40S, A41T, Y48H, G49A, V56I, I156L, P312S | |
NS4 (p22) | I4T, I14V, G64S, I121M, N151S, E157G, E163G/D | D69N, K84E, V88I, I106T | N53S |
NS5 (VPg) | T8I, R52K, I73V, K104R | ||
NS6 (Pro) | P43S, V153A | T37I, T69A | |
NS7 (RdRp) | V125A, T158S, I274V, E356D, N502D | K54R, V82I, A86S, H121Y, T137I, G138S, K236R, I261V, Q270H, I274K, E376G, K457R, I458V | G18S, T158S, K405R, N427S |