Fig. 4

Association between gut microbes and identified metabolites. (a) Differences in the composition of the gut microbiota between responders and non-responders. Genera with high bacterial abundance are shown in red (See supplemental Fig. 2). (b) Correlations between levels of the identified metabolites and the abundance of the identified genera. The numbers in the boxes are Pearson’s correlation coefficients. Yellow highlights denote statistical significance. (c) Correlation between metabolite levels and the abundance of genera in the validation set. Pearson’s correlation coefficients (R) and 95% confidence intervals (CIs) are shown for each curve. Data shown in red indicate |R|>0.4. Yellow-green areas denote the 95% CIs for the regression lines. (d) Changes in N-ε-acetyllysine levels, and in the abundance of Odoribacter, over time. P-values, calculated using the linear mixed model with Bonferroni correction, denote the significance of differences in trends between groups