Table 1 Participant characteristics

Non-responder

Responder

P value*

Non-responder

Remitter

P value*

(n = 9)

(n = 9)

(n = 10)

(n = 6)

Age [years]

Mean ± SD

51.0 ± 20.5

53.7 ± 15.2

0.76^a

49.5 ± 16.9

58.2 ± 25.2

0.48^a

Sex

n (%)

1.00^b

0.12^b

Men

3 (33.3)

4 (44.4)

7 (70.0)

1 (16.7)

Women

6 (66.7)

5 (55.6)

3 (30.0)

5 (83.3)

BMI [kg/m²]

Mean ± SD

21.0 ± 5.7

22.3 ± 3.2

0.58^a

23.1 ± 3.7

18.7 ± 1.6

0.006^a

Duration of disease [years]

Mean ± SD

14.7 ± 16.1

12.4 ± 8.7

0.72^a

9.7 ± 8.1

8.0 ± 7.7

0.69^a

Baseline symptom

n (%)

0.33^c

< 0.001^c

Remission

0 (0)

0 (0)

0 (0)

6 (100)

Anxiety alone

0 (0)

1 (11.1)

0 (0)

0 (0)

Depression alone

0 (0)

1 (11.1)

1 (10.0)

0 (0)

Both anxiety and depression

9 (100)

7 (77.8)

9 (90.0)

0 (0)

Baseline HAM-A score

Mean ± SD

20.8 ± 7.0

13.4 ± 6.1

0.03^a

16.1 ± 7.9

4.7 ± 1.8

0.001^a

Baseline HAM-D score

Mean ± SD

18.8 ± 7.6

14.6 ± 7.3

0.25^a

18.3 ± 6.3

4.0 ± 2.0

< 0.001^a

Baseline medications

Antidepressants

n (%)

6 (66.7)

9 (100)

0.21^c

8 (80.0)

5 (83.3)

1.00^c

Antipsychotics

n (%)

2 (22.2)

3 (33.3)

1.00^c

3 (30.0)

0 (0)

0.25^c

Dose of medication used during the study

Antidepressants [mg/day]^d

Mean ± SD

148 ± 162

203 ± 90

0.39^a

163 ± 123

63 ± 60

0.048^a

Antipsychotics [mg/day]^e

Mean ± SD

44 ± 97

97 ± 200

0.49^a

42 ± 102

0 ± 0

0.23^a

History of previous hospitalization

n (%)

4 (44.4)

6 (66.7)

0.64^b

5 (50.0)

2 (33.3)

0.63^b

Hospitalization during the study

n (%)

4 (44.4)

7 (77.8)

0.34^b

0 (0)

0 (0)

NA

ECT during the study

n (%)

0 (0)

4 (44.4)

0.08^b

0 (0)

0 (0)

NA