Table 3 The Prediction performance using logistic regression for each microbiota
Variables | AUC (95% CI) | Cut-off | SE (95% CI) | SP (95% CI) | PPV (95% CI) | NPV (95% CI) | Accuracy (95% CI) | |
|---|---|---|---|---|---|---|---|---|
Saliva | Neisseriaceae | 0.57 (0.38, 0.76) | 0.61943 | 0.61 (0.39, 0.80) | 0.67 (0.38, 0.88) | 0.74 (0.47, 0.88) | 0.53 (0.31, 0.81) | 0.61 (0.43, 0.76) |
Prevotellaceae | 0.59 (0.41, 0.78) | 0.66244 | 0.48 (0.27, 0.69) | 0.80 (0.52, 0.96) | 0.79 (0.50, 0.90) | 0.50 (0.29, 0.85) | 0.58 (0.41, 0.74) | |
Streptococcaceae | 0.64 (0.44, 0.83) | 0.56746 | 0.87 (0.66, 0.97) | 0.53 (0.27, 0.79) | 0.74 (0.48, 0.94) | 0.73 (0.44, 0.90) | 0.71 (0.54, 0.85) | |
Veillonellaceae | 0.54 (0.35, 0.73) | 0.60961 | 0.26 (0.10, 0.48) | 0.93 (0.68, 1.00) | 0.86 (0.48, 0.94) | 0.45 (0.21, 0.97) | 0.50 (0.33, 0.67) | |
Unclassified at family level | 0.70 (0.53, 0.87) | 0.60513 | 0.61 (0.39, 0.80) | 0.87 (0.60, 0.98) | 0.88 (0.61, 0.95) | 0.59 (0.37, 0.93) | 0.71 (0.54, 0.85) | |
Pasteurellaceae | 0.55 (0.35, 0.75) | 0.63407 | 0.65 (0.43, 0.84) | 0.53 (0.27, 0.79) | 0.68 (0.40, 0.85) | 0.50 (0.28, 0.76) | 0.53 (0.36, 0.69) | |
Porphyromonadaceae | 0.74 (0.58, 0.90) | 0.60168 | 0.57 (0.34, 0.77) | 0.80 (0.52, 0.96) | 0.81 (0.54, 0.92) | 0.55 (0.33, 0.87) | 0.61 (0.43, 0.76) | |
Firmicutes | 0.61 (0.42, 0.80) | 0.57158 | 0.78 (0.56, 0.93) | 0.53 (0.27, 0.79) | 0.72 (0.45, 0.90) | 0.62 (0.36, 0.84) | 0.68 (0.51, 0.82) | |
Proteobacteria | 0.60 (0.41, 0.78) | 0.62610 | 0.65 (0.43, 0.84) | 0.60 (0.32, 0.84) | 0.71 (0.44, 0.87) | 0.53 (0.31, 0.79) | 0.63 (0.46, 0.78) | |
Bacteroidetes | 0.60 (0.41, 0.78) | 0.62585 | 0.57 (0.34, 0.77) | 0.73 (0.45, 0.92) | 0.76 (0.49, 0.89) | 0.52 (0.31, 0.83) | 0.63 (0.46, 0.78) | |
Actinobacteria | 0.66 (0.48, 0.84) | 0.65617 | 0.52 (0.31, 0.73) | 0.93 (0.68, 1.00) | 0.92 (0.65, 0.97) | 0.56 (0.34, 0.98) | 0.68 (0.51, 0.82) | |
Fusobacteria | 0.73 (0.57, 0.89) | 0.64114 | 0.65 (0.43, 0.84) | 0.80 (0.52, 0.96) | 0.83 (0.57, 0.93) | 0.60 (0.37, 0.89) | 0.68 (0.51, 0.82) | |
Unclassified at phylum level | 0.64 (0.47, 0.82) | 0.62979 | 0.57 (0.34, 0.77) | 0.80 (0.52, 0.96) | 0.81 (0.54, 0.92) | 0.55 (0.33, 0.87) | 0.63 (0.46, 0.78) | |
Verrucomicrobia | 0.44 (0.24, 0.64) | 0.58570 | 0.91 (0.72, 0.99) | 0.20 (0.04, 0.48) | 0.64 (0.24, 0.94) | 0.60 (0.27, 0.85) | 0.61 (0.43, 0.76) | |
Cyanobacteria | 0.45 (0.26, 0.64) | 0.61070 | 0.13 (0.03, 0.34) | 1.00 (0.78, 1.00) | 1.00 (0.42, 1.00) | 0.43 (0.12, 1.00) | 0.47 (0.31, 0.64) | |
Spirochaetes | 0.45 (0.25, 0.65) | 0.57570 | 1.00 (0.85, 1.00) | 0.20 (0.04, 0.48) | 0.66 (0.26, 1.00) | 1.00 (0.43, 1.00) | 0.58 (0.41, 0.74) | |
Unclassified at species level | 0.52 (0.33, 0.71) | 0.61704 | 0.43 (0.23, 0.66) | 0.80 (0.52, 0.96) | 0.77 (0.47, 0.89) | 0.48 (0.27, 0.84) | 0.55 (0.38, 0.71) | |
Neisseria mucosa | 0.61 (0.43, 0.79) | 0.62068 | 0.57 (0.34, 0.77) | 0.80 (0.52, 0.96) | 0.81 (0.54, 0.92) | 0.55 (0.33, 0.87) | 0.58 (0.41, 0.74) | |
Prevotella melaninogenica | 0.66 (0.48, 0.85) | 0.58381 | 0.70 (0.47, 0.87) | 0.60 (0.32, 0.84) | 0.73 (0.46, 0.88) | 0.56 (0.33, 0.81) | 0.66 (0.49, 0.80) | |
Veillonella atypica | 0.49 (0.29, 0.69) | 0.59292 | 0.91 (0.72, 0.99) | 0.27 (0.08, 0.55) | 0.66 (0.31, 0.94) | 0.67 (0.33, 0.87) | 0.63 (0.46, 0.78) | |
Veillonella dispar | 0.56 (0.37, 0.75) | 0.59037 | 0.52 (0.31, 0.73) | 0.67 (0.38, 0.88) | 0.71 (0.43, 0.86) | 0.48 (0.27, 0.77) | 0.53 (0.36, 0.69) | |
Streptococcus tigurinus | 0.67 (0.49, 0.86) | 0.69117 | 0.52 (0.31, 0.73) | 0.87 (0.60, 0.98) | 0.86 (0.58, 0.94) | 0.54 (0.32, 0.92) | 0.63 (0.46, 0.78) | |
Streptococcus pseudopneumoniae | 0.67 (0.49, 0.84) | 0.72796 | 0.30 (0.13, 0.53) | 1.00 (0.78, 1.00) | 1.00 (0.63, 1.00) | 0.48 (0.25, 1.00) | 0.53 (0.36, 0.69) | |
Streptococcus infantis | 0.74 (0.57, 0.90) | 0.73146 | 0.61 (0.39, 0.80) | 0.87 (0.60, 0.98) | 0.88 (0.61, 0.95) | 0.59 (0.37, 0.93) | 0.71 (0.54, 0.85) | |
Stool | Prevotellaceae | 0.45 (0.24, 0.66) | 0.59528 | 1.00 (0.86, 1.00) | 0.21 (0.05, 0.51) | 0.69 (0.29, 1.00) | 1.00 (0.43, 1.00) | 0.72 (0.55, 0.85) |
Lachnospiraceae | 0.70 (0.50, 0.89) | 0.60186 | 0.88 (0.69, 0.97) | 0.57 (0.29, 0.82) | 0.79 (0.53, 0.95) | 0.73 (0.44, 0.90) | 0.77 (0.61, 0.89) | |
Ruminococcaceae | 0.48 (0.26, 0.69) | 0.63412 | 0.80 (0.59, 0.93) | 0.43 (0.18, 0.71) | 0.71 (0.42, 0.90) | 0.55 (0.30, 0.80) | 0.67 (0.50, 0.81) | |
Bacteroidaceae | 0.54 (0.34, 0.73) | 0.67614 | 0.28 (0.12, 0.49) | 0.93 (0.66, 1.00) | 0.88 (0.51, 0.95) | 0.42 (0.20, 0.97) | 0.51 (0.35, 0.68) | |
Unclassified at family level | 0.53 (0.34, 0.72) | 0.64502 | 0.52 (0.31, 0.72) | 0.64 (0.35, 0.87) | 0.72 (0.44, 0.86) | 0.43 (0.24, 0.74) | 0.56 (0.40, 0.72) | |
Enterobacteriaceae | 0.60 (0.42, 0.79) | 0.68041 | 0.40 (0.21, 0.61) | 0.86 (0.57, 0.98) | 0.83 (0.53, 0.92) | 0.44 (0.24, 0.88) | 0.56 (0.40, 0.72) | |
Clostridiaceae | 0.57 (0.37, 0.77) | 0.63297 | 0.72 (0.51, 0.88) | 0.50 (0.23, 0.77) | 0.72 (0.43, 0.88) | 0.50 (0.28, 0.77) | 0.64 (0.47, 0.79) | |
Flavobacteriaceae | 0.54 (0.34, 0.73) | 0.65106 | 0.44 (0.24, 0.65) | 0.79 (0.49, 0.95) | 0.79 (0.49, 0.90) | 0.44 (0.24, 0.81) | 0.44 (0.28, 0.60) | |
Alcaligenaceae | 0.57 (0.39, 0.76) | 0.95574 | 0.36 (0.18, 0.57) | 1.00 (0.77, 1.00) | 1.00 (0.68, 1.00) | 0.47 (0.25, 1.00) | 0.49 (0.32, 0.65) | |
Porphyromonadaceae | 0.52 (0.33, 0.70) | 0.68017 | 0.32 (0.15, 0.54) | 0.93 (0.66, 1.00) | 0.89 (0.55, 0.95) | 0.43 (0.22, 0.97) | 0.54 (0.37, 0.70) | |
Veillonellaceae | 0.60 (0.40, 0.81) | 0.63125 | 0.84 (0.64, 0.95) | 0.43 (0.18, 0.71) | 0.72 (0.43, 0.91) | 0.60 (0.34, 0.83) | 0.69 (0.52, 0.83) | |
Bacteroidetes | 0.58 (0.39, 0.77) | 0.68012 | 0.40 (0.21, 0.61) | 0.79 (0.49, 0.95) | 0.77 (0.47, 0.89) | 0.42 (0.23, 0.80) | 0.51 (0.35, 0.68) | |
Firmicutes | 0.53 (0.33, 0.74) | 0.63277 | 0.92 (0.74, 0.99) | 0.29 (0.08, 0.58) | 0.70 (0.34, 0.95) | 0.67 (0.33, 0.87) | 0.67 (0.50, 0.81) | |
Proteobacteria | 0.69 (0.50, 0.88) | 0.57792 | 0.80 (0.59, 0.93) | 0.64 (0.35, 0.87) | 0.80 (0.55, 0.93) | 0.64 (0.40, 0.87) | 0.72 (0.55, 0.85) | |
Unclassified at phylum level | 0.51 (0.31, 0.71) | 0.63133 | 0.80 (0.59, 0.93) | 0.36 (0.13, 0.65) | 0.69 (0.37, 0.88) | 0.50 (0.27, 0.77) | 0.64 (0.47, 0.79) | |
Actinobacteria | 0.47 (0.28, 0.66) | 0.70535 | 0.12 (0.03, 0.31) | 1.00 (0.77, 1.00) | 1.00 (0.42, 1.00) | 0.39 (0.11, 1.00) | 0.41 (0.26, 0.58) | |
Nitrospirae | 0.64 (0.44, 0.84) | 0.56291 | 1.00 (0.86, 1.00) | 0.29 (0.08, 0.58) | 0.71 (0.36, 1.00) | 1.00 (0.50, 1.00) | 0.74 (0.58, 0.87) | |
Cyanobacteria | 0.44 (0.24, 0.63) | 0.68098 | 0.12 (0.03, 0.31) | 1.00 (0.77, 1.00) | 1.00 (0.42, 1.00) | 0.39 (0.11, 1.00) | 0.44 (0.28, 0.60) | |
Chloroflexi | 0.60 (0.42, 0.79) | 0.59631 | 0.64 (0.43, 0.82) | 0.64 (0.35, 0.87) | 0.76 (0.49, 0.89) | 0.50 (0.29, 0.79) | 0.62 (0.45, 0.77) | |
Verrucomicrobia | 0.48 (0.28, 0.68) | 0.64675 | 0.68 (0.46, 0.85) | 0.43 (0.18, 0.71) | 0.68 (0.38, 0.85) | 0.43 (0.23, 0.71) | 0.59 (0.42, 0.74) | |
Unclassified at species level | 0.55 (0.34, 0.75) | 0.64183 | 0.60 (0.39, 0.79) | 0.64 (0.35, 0.87) | 0.75 (0.47, 0.88) | 0.47 (0.27, 0.77) | 0.59 (0.42, 0.74) | |
Prevotella copri | 0.46 (0.26, 0.67) | 0.61832 | 1.00 (0.86, 1.00) | 0.07 (0.00, 0.34) | 0.66 (0.04, 1.00) | 1.00 (0.20, 1.00) | 0.64 (0.47, 0.79) | |
Bacteroides vulgatus | 0.55 (0.35, 0.76) | 0.64071 | 0.56 (0.35, 0.76) | 0.64 (0.35, 0.87) | 0.74 (0.46, 0.87) | 0.45 (0.26, 0.76) | 0.56 (0.40, 0.72) | |
Escherichia albertii | 0.64 (0.45, 0.83) | 0.55030 | 0.80 (0.59, 0.93) | 0.50 (0.23, 0.77) | 0.74 (0.46, 0.91) | 0.58 (0.34, 0.82) | 0.67 (0.50, 0.81) | |
Bacteroides fragilis | 0.56 (0.36, 0.76) | 0.66099 | 0.48 (0.28, 0.69) | 0.79 (0.49, 0.95) | 0.80 (0.51, 0.90) | 0.46 (0.26, 0.83) | 0.51 (0.35, 0.68) |