Fig. 2

Venn diagram of significant metabolites across all six time points of TBM treatment. Number of cases according to TBM stages per time point are given in square brackets. Abbreviations: 2HGA, 2-hydroxyglutaric acid; 3HIA, 3-hydroxyisovaleric acid; 3MGA, 3-methylglutaconic acid; 4HPAA:4-hydroxyphenylacetic acid; AA, aconitic acid; EA, ethylmalonic acid; GA, glucaric acid; HG, hexanoylglycine; ICA, isocitric acid; NAAA, N-acetylaspartic acid; NAP, N-acetylphenylalanine; VA, vanillactic acid; 2HAA, 2-hydroxyadipic acid; 2HPAA, 2-hydroxyphenylacetic acid; 2KGA, 2-ketoglutaric acid; 2MBG, 2-methylbutyrylglycine; 2ODA, 2-octenedioic acid; 2,3PCA, 2,3-pyridinecarboxylic acid; 3HGA, 3-hydroxyglutaric acid; 3HPA, 3-hydroxypropionic acid; 3MCG, 3-methylcrotonylglycine; 3,4DHPAA, 3,4-dihydroxyphenylacetic acid; 4-H-3MMA, 4-hydroxy-3-methoxymandelic acid; 4HPLA, 4-hydroxyphenyllactic acid; 4HHA, 4-hydroxyhippuricacid; 5HIAA, 5-hydroxyindoleacetic acid; 5HHA, 5-hydroxyhexanoic acid; BG, buterylglycine; HA, homovanillic acid; IG, isobutyrylglycine; MCA, methylcitric acid; MSA, methylsuccinic acid; NAT, N acetyltyrosine; PAG, phenylacetylglutamine; PA, pimelic acid; SA, suberic acid; TG, tiglylglycine