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Fig. 5 | Gut Pathogens

Fig. 5

From: Urinary markers of Mycobacterium tuberculosis and dysbiosis in paediatric tuberculous meningitis cases undergoing treatment

Fig. 5

Branched-chain amino acid (BCAA) catabolism (in the host: red; and as co-metabolism (both host and microbial): purple). Elevated 3-methylcrotonylglycine (3MCG), isobutyrylglycine (IG), and 2-methylbutyrylglycine (2MBG) are urinary markers of dysbiosis at T1 of TBM treatment. It should be noted that the three BCAA intermediates (3-methylbutaonyl-CoA, isobutyrl-CoA and 2-methylbutanoly-CoA) can also be linked to branched-chain fatty acids that are specific to deterioration of the unique cell wall of M. tb (microbial specific: blue). Propionyl-CoA is also an end product that can be linked to Fig. 6

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Gut Pathogens

ISSN: 1757-4749