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Table 3 ROC-curve results for tail moment of brain cortex and medulla of the different studied groups showing AUC, best cut-off values, specificity and sensitivity

From: The neurotoxic effect of clindamycin - induced gut bacterial imbalance and orally administered propionic acid on DNA damage assessed by the comet assay: protective potency of carnosine and carnitine

Parameter Group Area under the curve Best cutoff value Sensitivity % Specificity %
Cortex Propionic acid 1.000 19.465 100.0% 100.0%
Clindamycin 1.000 1.968 100.0% 100.0%
Carnosine 0.667 0.720 100.0% 66.7%
Carnitine 0.667 0.950 100.0% 66.7%
Propionic acid+Carnosine 1.000 7.640 100.0% 100.0%
Propionic acid+Carnitine 1.000 5.642 100.0% 100.0%
Clindamycin +Carnosine 1.000 1.822 100.0% 100.0%
Clindamycin +Carnitine 1.000 1.931 100.0% 100.0%
Medulla Propionic acid 1.000 17.147 100.0% 100.0%
Clindamycin 1.000 1.910 100.0% 100.0%
Carnosine 0.556 1.209 66.7% 66.7%
Carnitine 0.444 0.882 100.0% 33.3%
Propionic acid+Carnosine 1.000 6.954 100.0% 100.0%
Propionic acid+Carnitine 1.000 3.905 100.0% 100.0%
Clindamycin +Carnosine 1.000 1.794 100.0% 100.0%
  Clindamycin +Carnitine 1.000 1.963 100.0% 100.0%