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Table 3 ROC-curve results for tail moment of brain cortex and medulla of the different studied groups showing AUC, best cut-off values, specificity and sensitivity

From: The neurotoxic effect of clindamycin - induced gut bacterial imbalance and orally administered propionic acid on DNA damage assessed by the comet assay: protective potency of carnosine and carnitine

Parameter

Group

Area under the curve

Best cutoff value

Sensitivity %

Specificity %

Cortex

Propionic acid

1.000

19.465

100.0%

100.0%

Clindamycin

1.000

1.968

100.0%

100.0%

Carnosine

0.667

0.720

100.0%

66.7%

Carnitine

0.667

0.950

100.0%

66.7%

Propionic acid+Carnosine

1.000

7.640

100.0%

100.0%

Propionic acid+Carnitine

1.000

5.642

100.0%

100.0%

Clindamycin +Carnosine

1.000

1.822

100.0%

100.0%

Clindamycin +Carnitine

1.000

1.931

100.0%

100.0%

Medulla

Propionic acid

1.000

17.147

100.0%

100.0%

Clindamycin

1.000

1.910

100.0%

100.0%

Carnosine

0.556

1.209

66.7%

66.7%

Carnitine

0.444

0.882

100.0%

33.3%

Propionic acid+Carnosine

1.000

6.954

100.0%

100.0%

Propionic acid+Carnitine

1.000

3.905

100.0%

100.0%

Clindamycin +Carnosine

1.000

1.794

100.0%

100.0%

 

Clindamycin +Carnitine

1.000

1.963

100.0%

100.0%