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Table 2 Summary of common knockout genes used in murine models of intestinal inflammation

From: Animal models to study acute and chronic intestinal inflammation in mammals

Genes Function Immunity affected Reference
IL-10 Cytokine involved in anti-inflammatory and regulatory pathways Adaptive [57, 64, 296, 297]
IL-23R Th17 cytokine; T-cell differentiation Adaptive [296]
CD4+CD25+ Regulatory T-cell adaptor glycoproteins Adaptive [296, 297]
NOD2/CARD15 Intracellular bacterial peptidoglycan receptor/apoptotic protein Innate [296]
TGF-β1 Regulatory cytokine; inhibits effector T-cell development, downregulates immune response Adaptive [297]
RAG Protein; B and T lymphocyte maturation Adaptive [57, 64, 296]
ATG16L1 Autophagy gene involved in pathogen regulation Innate and adaptive [296]
APCmin/+ Gene; Β-catenin regulator involved in CRC development Innate [64]
IL-2 Pro-inflammatory cytokine Adaptive [57]
TNF-α Th1 cytokine; apoptotic signal activation Innate and adaptive [57]
STAT3 Signalling molecule; intestinal mucosa regeneration post injury Adaptive [296]
NFκB Transcription factor; pro-inflammatory cytokines and cell survival factors Adaptive [57, 296]
Muc2 Gene; mucin, main constituent of intestinal mucus, physical barrier formation Innate and adaptive [296]
IFN-γ Pro-inflammatory cytokine Innate and adaptive [57]
MyD88 Transcription factor; signalling molecule for TLR and NFκB Innate and adaptive [64]
TLR Family of receptors for identification of various microbial surface proteins Innate [64]