Klebsiella pneumoniae is the most common pathogen of community-acquired pyogenic liver abscess in East Asia. Diabetes mellitus (DM) is a well-established risk factor for K. pneumoniae ...
Authors: Chien Chuang, Wen-Chien Fan, Yi-Tsung Lin and Fu-Der Wang
Most recently we reported that RHB‑104 triple antibiotics combination in culture is bactericidal and should be effective for treatment of Crohn’s disease (CD)-associated with Mycobacterium avium subspecies paratu...
Authors: Ahmad Qasem, Mitra Safavikhasraghi and Saleh A. Naser
The emerging enteric pathogen Campylobacter concisus is associated with prolonged diarrhea and inflammatory bowel disease. Previous studies have shown that C. concisus strains are very genetically diverse. Nevert...
Authors: Hans Linde Nielsen, Henrik Nielsen and Mia Torpdahl
We previously showed that zonula occludens toxin (Zot) encoded by Campylobacter concisus zot808T gene has the potential to initiate inflammatory bowel disease. This Zot protein caused ...
Authors: Fang Liu, Hoyul Lee, Ruiting Lan and Li Zhang
Hepatitis C virus (HCV) causes debilitating liver diseases, which may progress to cirrhosis and cancer, and claims 500,000 annual lives worldwide. While HCV epidemiology, pathophysiology, and therapy are being...
Authors: AbdelRahman Mahmoud Aly, AbdelReheem Adel, Ahmed Osama El-Gendy, Tamer M. Essam and Ramy K. Aziz
Cold atmospheric plasma could
constitute an alternative against multi-drug resistant pathogens. Susceptibility of enterococci to cold atmospheric plasma was investigated in vitro.
Authors: Matthias Napp, Sebastian von Podewils, Ingo Klare, Hermann Haase, Richard Kasch, Denis Gümbel, Axel Ekkernkamp, Michael Jünger and Georg Daeschlein
The human and animal intestinal tract harbors a complex community of microbes which enables bacteria to inherit antibiotic resistance genes. The aims of this study were to investigate clonality, antimicrobial ...
Thermophilic Campylobacter species are a major cause of bacterial foodborne diarrhoea in humans worldwide. Poultry and their products are the predominant source for human campylobacteriosis. Resistance of Campylo...
Authors: Tuan Ngoc Minh Nguyen, Helmut Hotzel, John Njeru, Joyce Mwituria, Hosny El-Adawy, Herbert Tomaso, Heinrich Neubauer and Hafez M. Hafez
Multidrug resistance in Acinetobacter baumannii has dramatically increased in recent years worldwide. Thus, last-line antibiotics like carbapenems are increasingly being used which in turn further augments select...
Authors: Christa Ewers, Peter Klotz, Sandra Scheufen, Ursula Leidner, Stephan Göttig and Torsten Semmler
Infantile eczema is an immunological disease that is characterized by itchy and dry skin. Recent studies have suggested that gut microbiota (GM) plays a role in the development and progression of eczema. To fu...
Klebsiella pneumoniae subsp. pneumoniae KP617 is a pathogenic strain that coproduces OXA-232 and NDM-1 carbapenemases. We sequenced the genome of KP617, which was isolated from the wou...
Authors: Taesoo Kwon, Young-Hee Jung, Sanghyun Lee, Mi-ran Yun, Won Kim and Dae-Won Kim
Human Campylobacter jejuni infections are worldwide on the rise. Information about the distinct molecular mechanisms underlying campylobacteriosis, however, are scarce. In the present study we investigated whethe...
Authors: Markus M. Heimesaat, Ursula Grundmann, Marie E. Alutis, André Fischer, Ulf B. Göbel and Stefan Bereswill
Increased intestinal permeability and translocation of gut microbiota from the intestinal lumen to the systemic circulation predispose patients to various diseases and may be one of the main triggers thereof. ...
Vibrio vulnificus, a resident in the human gut, is frequently found in seafood, causing food-borne illnesses including gastroenteritis and severe septicemia. While V. vulnificus has be...
Authors: Han Young Chung, You-Tae Kim, Suyeon Kim, Eun Jung Na, Hye-Jin Ku, Keun Hwa Lee, Sang Taek Heo, Sangryeol Ryu, Heebal Kim, Sang Ho Choi and Ju-Hoon Lee
Mycobacterium avium subspecies paratuberculosis (MAP) has been implicated as an etiological agent of Crohn’s disease (CD), a debilitating chronic inflammatory bowel disease. Clarithrom...
Authors: Karel P. Alcedo, Saisathya Thanigachalam and Saleh A. Naser
Diarrhea is one of the main causes of morbidity and mortality among children less than 5 years of age worldwide, and its causes vary by region. This study aimed to determine the etiologic spectrum, prevalent c...
Authors: Mei Qu, Bing Lv, Xin Zhang, Hanqiu Yan, Ying Huang, Haikun Qian, Bo Pang, Lei Jia, Biao Kan and Quanyi Wang
Ducks (Anas platyrhynchos) an economically important waterfowl for meat, eggs and feathers; is also a natural reservoir for influenza A viruses. The emergence of novel viruses is attributed to the status of co-ex...
Authors: Mohammed Fawaz, Periyasamy Vijayakumar, Anamika Mishra, Pradeep N. Gandhale, Rupam Dutta, Nitin M. Kamble, Shashi B. Sudhakar, Parimal Roychoudhary, Himanshu Kumar, Diwakar D. Kulkarni and Ashwin Ashok Raut
The cell adhesion and tumor suppressor protein E-cadherin is an important factor in the establishment and maintenance of epithelial integrity. E-cadherin is a single transmembrane protein, which consists of an...
Authors: Thomas P. Schmidt, Camilla Goetz, Markus Huemer, Gisbert Schneider and Silja Wessler
Thuricin CD is a two-component antimicrobial, belonging to the recently designated sactibiotic subclass of bacteriocins. The aim of this study was to investigate the effects of thuricin CD, as well as the anti...
Authors: Harsh Mathur, Mary C. Rea, Paul D. Cotter, Colin Hill and R. Paul Ross
The need for organic food of animal origin has increased rapidly in recent years. However, effects of organic animal husbandry on food safety have not been rigorously tested especially in meat turkey flocks. T...
Authors: Marwa Fawzy El Metwaly Ahmed, Hosny El-Adawy, Helmut Hotzel, Herbert Tomaso, Heinrich Neubauer, Nicole Kemper, Joerg Hartung and Hafez Mohamed Hafez
Campylobacter concisus is a commensal of the human oral flora that has been linked to prolonged diarrhea and inflammatory bowel disease (IBD). It has been detected more often from inte...
Authors: Karina Frahm Kirk, Hans Linde Nielsen, Ole Thorlacius-Ussing and Henrik Nielsen
Salmonella enterica is the zoonotic agent most frequently responsible for foodborne infections in humans worldwide. In this work the presence of S. enterica was investigated in 734 uni...
Authors: Ilaria Frasson, Sabrina Bettanello, Ettore De Canale, Sara N. Richter and Giorgio Palù
A variety of microbial communities exist throughout the human and animal body. Genetics, environmental factors and long-term dietary habit contribute to shaping the composition of the gut microbiota. For this ...
Authors: Tewodros Debebe, Susanne Holtze, Michaela Morhart, Thomas Bernd Hildebrandt, Steffen Rodewald, Klaus Huse, Matthias Platzer, Dereje Wyohannes, Salomon Yirga, Alemayehu Lemma, Rene Thieme, Brigitte König and Gerd Birkenmeier
The advent and use of highly sensitive molecular biology techniques to explore the microbiota and microbiome in environmental and tissue samples have detected the presence of contaminating microbial DNA within...
Authors: Angela Glassing, Scot E. Dowd, Susan Galandiuk, Brian Davis and Rodrick J. Chiodini
Vibrio parahaemolyticus is a Gram-negative halophilic bacterium which is found largely in estuarine and coastal waters. The bacteria has been a main focus in gastro-intestinal infectio...
Campylobacter concisus is a Gram-negative bacterium that is associated with inflammatory bowel disease (IBD). Some C. concisus strains carry zonula occludens toxin (zot) gene which has...
Authors: Vikneswari Mahendran, Fang Liu, Stephen M. Riordan, Michael C. Grimm, Mark M. Tanaka and Li Zhang
Campylobacter species are recognized as the most common cause of foodborne bacterial gastroenteritis in humans. In this study nine Campylobacter strains isolated from chicken meat and ...
Authors: Tuan Ngoc Minh Nguyen, Helmut Hotzel, Hosny El-Adawy, Hanh Thi Tran, Minh Thi Hong Le, Herbert Tomaso, Heinrich Neubauer and Hafez Mohamed Hafez
Factors like ethnicity, diet and age of an individual have been hypothesized to play a role in determining the makeup of gut microbiome. In order to investigate the gut microbiome structure as well as the inte...
Authors: Deepak Yadav, Tarini Shankar Ghosh and Sharmila S. Mande
Salmonella enterica serovar Enteritidis (S. Enteritidis) is a human and animal pathogen that causes gastroenteritis characterized by inflammatory diarrhea and occasionally an invasive ...
Authors: Jacob R. Elder, Kim Lam Chiok, Narayan C. Paul, Gary Haldorson, Jean Guard and Devendra H. Shah
Macrobrachium rosenbergii is well-known as the giant freshwater prawn, and is a commercially significant source of seafood. Its production can be affected by various bacterial contaminati...
The non-shiga toxin-producing Escherichia coli (non-STEC) O157 is a pathogenic strain that cause diarrhea but does not cause hemolytic-uremic syndrome, or hemorrhagic colitis. Here, we present the 5-Mb draft geno...
Authors: Taesoo Kwon, Jung-Beom Kim, Young-Seok Bak, Young-Bin Yu, Ki Sung Kwon, Won Kim and Seung-Hak Cho
Typhoid fever has caused severe epidemics in many Asian and African countries. The early detection of outbreaks and their sources may promote the prevention and control of typhoid fever, for which effective an...
Authors: Hongxia Wang, Baowei Diao, Zhigang Cui, Meiying Yan and Biao Kan
Peptoclostridium (Clostridium) difficile is a spore-forming bacterium responsible for nosocomial infections in humans. It is recognized as an important agent of diarrhea and colitis in...
Authors: Felipe L. Pereira, Carlos A. Oliveira Júnior, Rodrigo O. S. Silva, Fernanda A. Dorella, Alex F. Carvalho, Gabriel M. F. Almeida, Carlos A. G. Leal, Francisco C. F. Lobato and Henrique C. P. Figueiredo
Almost all Helicobacter pylori infected person develop gastritis and severe gastritis is supposed to be the denominator of peptic ulcer diseases, which may lead to gastric cancer. However, it is still an enigma w...
Authors: Mou Ganguly, Sagartirtha Sarkar, Prachetash Ghosh, Avijit Sarkar, Jawed Alam, Bipul Chandra Karmakar, Ronita De, Dhira Rani Saha and Asish K. Mukhopadhyay
Mycobacterium avium subspecies paratuberculosis (Map) causes Johne’s disease in domestic and wild ruminants. It has been a debate that whether Map can cause Crohn’s disease in human. T...
Authors: Ruichao Yue, Chunfa Liu, Paul Barrow, Fei Liu, Yongyong Cui, Lifeng Yang, Deming Zhao and Xiangmei Zhou
It has been suggested that the prevalence of Helicobacter pylori infection has stabilized in the USA and is decreasing in China. We conducted a systematic literature analysis to test this hypothesis. PubMed and E...
Authors: Peter Nagy, Saga Johansson and Michael Molloy-Bland
This study was designed to determine the relationship between Mycobacterium avium subspecies paratuberculosis (MAP) infection and selenium-dependent glutathione peroxidase (GPx) activity, in the blood of humans a...
Authors: Ahmad Qasem, Ahmad Abdel-Aty, Huda Abu-Suwa and Saleh A. Naser
Pathogenic strains in Escherichia coli can be divided into several pathotypes according to their virulence features. Among them, uropathogenic E. coli causes most of the urinary tract infections and has a genotyp...
Authors: Min-Jung Kwak, Myung-Soo Kim, Soon-Kyeong Kwon, Seung-Hak Cho and Jihyun F. Kim
Sphingolipids are important for innate immune response to eliminate infected pathogens and involved in autophagy. On the other hand, nucleotide-binding oligomerization domain-containing protein 2 (NOD2) served...
The virulence role of surface antigens in a single serotype of Klebsiella pneumoniae strain have been studied, but little is known about whether their contribution will vary with serotype.
Intestinal microorganisms affect host physiology, including ageing. Given the difficulty in controlling for human studies of the gut microbiome, mouse models provide an alternative avenue to study such relatio...
Authors: Sooyeon Lim, Dong-Ho Chang, Sharon Ahn and Byoung-Chan Kim
Pneumocystis carinii pneumonia occasionally appears in immunodeficient patients. While several reports have shown that Pneumocystis carinii pneumonia occurred in the early phase of sta...
The babA2 gene along with the cagA and vacA of Helicobacter pylori has been considered as a risk factor for the disease outcome in certain populations. This study was aimed to understand the role of babA2 of H. p...
Authors: Prachetash Ghosh, Avijit Sarkar, Mou Ganguly, Raghwan, Jawed Alam, Ronita De and Asish K. Mukhopadhyay
Recent research suggests integration of the intestinal
microbiota in gut-brain communication which could lead to new approaches to treat neurological disorders. The highly social prairie voles are an excellen...
Authors: Senait Assefa, Kathleen Ahles, Simone Bigelow, J. Thomas Curtis and Gerwald A. Köhler
The worldwide increase of food-borne infections with antibiotic resistant pathogens constitutes a major public health problem. Therefore, this study aimed to determine the prevalence, antibiogram, virulence ge...
Authors: Rasha M. Gharieb, Yasmine H. Tartor and Mariam H. E. Khedr
Rapid commercial assays, including nucleic acid amplification tests and immunoassays for Clostridium. difficile toxins, have replaced the use of older assays. They are included in a two-step algorithm diagnosis, ...
Authors: J. Goret, J. Blanchi, C. Eckert, S. Lacome, A. Petit, F. Barbut, C. Bébéar and Francis Mégraud
Disturbances in the intestinal microbial community (i.e. dysbiosis) or presence of the microbes with deleterious effects on colonic mucosa has been linked to the pathogenesis of inflammatory bowel diseases. Ho...
Authors: Zhengyu Du, Tomas Hudcovic, Jakub Mrazek, Hana Kozakova, Dagmar Srutkova, Martin Schwarzer, Helena Tlaskalova-Hogenova, Martin Kostovcik and Miloslav Kverka
