Clostridium difficile (CD), a spore-forming and toxin-producing bacterium, is the main cause for antibiotic-associated diarrhea in the elderly. Here we investigated CD colonization in ...
Authors: Sophie Fehlbaum, Christophe Chassard, Sophie Annick Poeker, Muriel Derrien, Candice Fourmestraux and Christophe Lacroix
Enterococcus faecalis, the type strain of the genus Enterococcus, is not only a commensal bacterium in the gastrointestinal tract in vertebrates and invertebrates, but also causes seri...
Authors: Joon Yong Kim, Hye Seon Song, Yeon Bee Kim, Joseph Kwon, Jong-Soon Choi, Yong-Joon Cho, Byung-Yong Kim, Jin-Kyu Rhee, Jinjong Myoung, Young-Do Nam and Seong Woon Roh
Mouse infection studies have shown that interferon-γ (IFN-γ), a T helper 1 (Th1) cytokine, is required for the development of severe pathology induced by chronic Helicobacter infection. This finding is largely ba...
Authors: Michelle Chonwerawong, Patrick Avé, Michel Huerre and Richard L. Ferrero
More than 50 years after the discovery of antibiotics, bacterial infections have decreased substantially; however, antibiotics also may have negative effects such as increasing susceptibility to pathogens. An ...
Authors: Tadasu Iizumi, Takako Taniguchi, Wataru Yamazaki, Geraldine Vilmen, Alexander V. Alekseyenko, Zhan Gao, Guillermo I. Perez Perez and Martin J. Blaser
Foodborne illness can occur due to various pathogenic bacteria such as Staphylococcus aureus, Escherichia coli and Vibrio parahaemolyticus, and can cause severe gastroenteritis symptoms. In this study, we complet...
Authors: Sojin Ahn, Han Young Chung, Sooyeon Lim, Kwondo Kim, Suyeon Kim, Eun Jung Na, Kelsey Caetano-Anolles, Ju-Hoon Lee, Sangryeol Ryu, Sang Ho Choi and Heebal Kim
Acute diarrhea is one of the major public health problems worldwide. Most of studies on acute diarrhea have been made on infants aged below 5 years and few efforts have been made to identify the etiological ag...
The Shiga toxin–producing Escherichia coli (STEC) O91:H21 strains NCCP15736 and NCCP15737 were isolated during a single outbreak in Korea, NCCP15736 from a symptomatic carrier and NCCP15737 from an asymptomatic c...
Authors: Taesoo Kwon, Young-Seok Bak, Young-Hee Jung, Young-Bin Yu, Jong Tae Choi, Cheorl-Ho Kim, Jung-Beom Kim, Won Kim and Seung-Hak Cho
Chickens are regarded as the main reservoir for human campylobacteriosis. Little is known about the interaction between Campylobacter jejuni (C. jejuni) and chickens. This interaction may be influenced by the sta...
Authors: Zifeng Han, Thomas Willer, Colin Pielsticker, Lenka Gerzova, Ivan Rychlik and Silke Rautenschlein
Staphylococcus xylosus is coagulase-negative staphylococci (CNS), found occasionally on the skin of humans but recurrently on other mammals. Recent reports suggest that this commensal ...
Authors: Gurwinder Kaur, Amit Arora, Sathyaseelan Sathyabama, Nida Mubin, Sheenam Verma, Shanmugam Mayilraj and Javed N. Agrewala
Helicobacter pylori is a pathogenic bacterium that causes various gastrointestinal diseases. The most common gastric malignancies associated with H. pylori are gastric cancer and lymph...
Human astroviruses (HAstVs) are commonly identified worldwide as important aetiological agents of acute gastroenteritis in all age groups. More and more evidences challenged the paradigm that AstV infections a...
Authors: Xiaochun Wang, Jinxin Wang, Chenglin Zhou, Shixing Yang, Quan Shen, Wen Zhang and Dunwu Qi
Human parechovirus (HPeV) is a genus of virus in the family Picornaviridae, having two species A and B. HPeVs are common infectious agents, usually causing mild diarrhea and respiratory disease in young children.
Rotavirus vaccines have poor efficacy in infants from low- and middle-income countries. Gut microbiota is thought to influence the immune response to oral vaccines. Thus, we developed a gnotobiotic (Gn) pig mo...
Authors: Erica L. Twitchell, Christine Tin, Ke Wen, Husen Zhang, Sylvia Becker-Dreps, M. Andrea Azcarate-Peril, Samuel Vilchez, Guohua Li, Ashwin Ramesh, Mariah Weiss, Shaohua Lei, Tammy Bui, Xingdong Yang, Stacey Schultz-Cherry and Lijuan Yuan
Human are confronted on a daily basis with contaminant pesticide residues in food, water and other components of the environment. Although the digestive system is the first organ to come into contact with food...
Authors: Claire Joly Condette, Bertin Elion Dzon, Farida Hamdad, Maurice Biendo, Véronique Bach and Hafida Khorsi-Cauet
In the winter of 2014–2015, a novel norovirus (NoV) strain (GII.17) was reported to be the major cause of gastroenteritis outbreaks in East Asia. To determine the time course of gastroenteritis infections asso...
Authors: Lifeng Pan, Caoyi Xue, Huiqin Fu, Dan Liu, Linying Zhu, Chang Cui, Weiping Zhu, Yifei Fu and Sun Qiao
Campylobacter species are the major food-borne pathogens which could cause bacterial gastroenteritis in humans. Contaminated chicken products have been recognized as the primary vehicl...
Chryseobacterium indologenes is an emerging opportunistic pathogen in hospital-acquired infection, which is intrinsically resistant to most antimicrobial agents against gram-negative b...
Authors: Tingting Wang, Xiawei Jiang, Chunyan Feng, Ang Li, Huihui Dong, Shaoqiang Wu and Beiwen Zheng
Klebsiella pneumoniae is the most common pathogen of community-acquired pyogenic liver abscess in East Asia. Diabetes mellitus (DM) is a well-established risk factor for K. pneumoniae ...
Authors: Chien Chuang, Wen-Chien Fan, Yi-Tsung Lin and Fu-Der Wang
Most recently we reported that RHB‑104 triple antibiotics combination in culture is bactericidal and should be effective for treatment of Crohn’s disease (CD)-associated with Mycobacterium avium subspecies paratu...
Authors: Ahmad Qasem, Mitra Safavikhasraghi and Saleh A. Naser
The emerging enteric pathogen Campylobacter concisus is associated with prolonged diarrhea and inflammatory bowel disease. Previous studies have shown that C. concisus strains are very genetically diverse. Nevert...
Authors: Hans Linde Nielsen, Henrik Nielsen and Mia Torpdahl
We previously showed that zonula occludens toxin (Zot) encoded by Campylobacter concisus zot808T gene has the potential to initiate inflammatory bowel disease. This Zot protein caused ...
Authors: Fang Liu, Hoyul Lee, Ruiting Lan and Li Zhang
Hepatitis C virus (HCV) causes debilitating liver diseases, which may progress to cirrhosis and cancer, and claims 500,000 annual lives worldwide. While HCV epidemiology, pathophysiology, and therapy are being...
Authors: AbdelRahman Mahmoud Aly, AbdelReheem Adel, Ahmed Osama El-Gendy, Tamer M. Essam and Ramy K. Aziz
Cold atmospheric plasma could
constitute an alternative against multi-drug resistant pathogens. Susceptibility of enterococci to cold atmospheric plasma was investigated in vitro.
Authors: Matthias Napp, Sebastian von Podewils, Ingo Klare, Hermann Haase, Richard Kasch, Denis Gümbel, Axel Ekkernkamp, Michael Jünger and Georg Daeschlein
The human and animal intestinal tract harbors a complex community of microbes which enables bacteria to inherit antibiotic resistance genes. The aims of this study were to investigate clonality, antimicrobial ...
Thermophilic Campylobacter species are a major cause of bacterial foodborne diarrhoea in humans worldwide. Poultry and their products are the predominant source for human campylobacteriosis. Resistance of Campylo...
Authors: Tuan Ngoc Minh Nguyen, Helmut Hotzel, John Njeru, Joyce Mwituria, Hosny El-Adawy, Herbert Tomaso, Heinrich Neubauer and Hafez M. Hafez
Multidrug resistance in Acinetobacter baumannii has dramatically increased in recent years worldwide. Thus, last-line antibiotics like carbapenems are increasingly being used which in turn further augments select...
Authors: Christa Ewers, Peter Klotz, Sandra Scheufen, Ursula Leidner, Stephan Göttig and Torsten Semmler
Infantile eczema is an immunological disease that is characterized by itchy and dry skin. Recent studies have suggested that gut microbiota (GM) plays a role in the development and progression of eczema. To fu...
Klebsiella pneumoniae subsp. pneumoniae KP617 is a pathogenic strain that coproduces OXA-232 and NDM-1 carbapenemases. We sequenced the genome of KP617, which was isolated from the wou...
Authors: Taesoo Kwon, Young-Hee Jung, Sanghyun Lee, Mi-ran Yun, Won Kim and Dae-Won Kim
Human Campylobacter jejuni infections are worldwide on the rise. Information about the distinct molecular mechanisms underlying campylobacteriosis, however, are scarce. In the present study we investigated whethe...
Authors: Markus M. Heimesaat, Ursula Grundmann, Marie E. Alutis, André Fischer, Ulf B. Göbel and Stefan Bereswill
Increased intestinal permeability and translocation of gut microbiota from the intestinal lumen to the systemic circulation predispose patients to various diseases and may be one of the main triggers thereof. ...
Vibrio vulnificus, a resident in the human gut, is frequently found in seafood, causing food-borne illnesses including gastroenteritis and severe septicemia. While V. vulnificus has be...
Authors: Han Young Chung, You-Tae Kim, Suyeon Kim, Eun Jung Na, Hye-Jin Ku, Keun Hwa Lee, Sang Taek Heo, Sangryeol Ryu, Heebal Kim, Sang Ho Choi and Ju-Hoon Lee
Mycobacterium avium subspecies paratuberculosis (MAP) has been implicated as an etiological agent of Crohn’s disease (CD), a debilitating chronic inflammatory bowel disease. Clarithrom...
Authors: Karel P. Alcedo, Saisathya Thanigachalam and Saleh A. Naser
Diarrhea is one of the main causes of morbidity and mortality among children less than 5 years of age worldwide, and its causes vary by region. This study aimed to determine the etiologic spectrum, prevalent c...
Authors: Mei Qu, Bing Lv, Xin Zhang, Hanqiu Yan, Ying Huang, Haikun Qian, Bo Pang, Lei Jia, Biao Kan and Quanyi Wang
Ducks (Anas platyrhynchos) an economically important waterfowl for meat, eggs and feathers; is also a natural reservoir for influenza A viruses. The emergence of novel viruses is attributed to the status of co-ex...
Authors: Mohammed Fawaz, Periyasamy Vijayakumar, Anamika Mishra, Pradeep N. Gandhale, Rupam Dutta, Nitin M. Kamble, Shashi B. Sudhakar, Parimal Roychoudhary, Himanshu Kumar, Diwakar D. Kulkarni and Ashwin Ashok Raut
The cell adhesion and tumor suppressor protein E-cadherin is an important factor in the establishment and maintenance of epithelial integrity. E-cadherin is a single transmembrane protein, which consists of an...
Authors: Thomas P. Schmidt, Camilla Goetz, Markus Huemer, Gisbert Schneider and Silja Wessler
The need for organic food of animal origin has increased rapidly in recent years. However, effects of organic animal husbandry on food safety have not been rigorously tested especially in meat turkey flocks. T...
Authors: Marwa Fawzy El Metwaly Ahmed, Hosny El-Adawy, Helmut Hotzel, Herbert Tomaso, Heinrich Neubauer, Nicole Kemper, Joerg Hartung and Hafez Mohamed Hafez
Thuricin CD is a two-component antimicrobial, belonging to the recently designated sactibiotic subclass of bacteriocins. The aim of this study was to investigate the effects of thuricin CD, as well as the anti...
Authors: Harsh Mathur, Mary C. Rea, Paul D. Cotter, Colin Hill and R. Paul Ross
Campylobacter concisus is a commensal of the human oral flora that has been linked to prolonged diarrhea and inflammatory bowel disease (IBD). It has been detected more often from inte...
Authors: Karina Frahm Kirk, Hans Linde Nielsen, Ole Thorlacius-Ussing and Henrik Nielsen
Salmonella enterica is the zoonotic agent most frequently responsible for foodborne infections in humans worldwide. In this work the presence of S. enterica was investigated in 734 uni...
Authors: Ilaria Frasson, Sabrina Bettanello, Ettore De Canale, Sara N. Richter and Giorgio Palù
A variety of microbial communities exist throughout the human and animal body. Genetics, environmental factors and long-term dietary habit contribute to shaping the composition of the gut microbiota. For this ...
Authors: Tewodros Debebe, Susanne Holtze, Michaela Morhart, Thomas Bernd Hildebrandt, Steffen Rodewald, Klaus Huse, Matthias Platzer, Dereje Wyohannes, Salomon Yirga, Alemayehu Lemma, Rene Thieme, Brigitte König and Gerd Birkenmeier
The advent and use of highly sensitive molecular biology techniques to explore the microbiota and microbiome in environmental and tissue samples have detected the presence of contaminating microbial DNA within...
Authors: Angela Glassing, Scot E. Dowd, Susan Galandiuk, Brian Davis and Rodrick J. Chiodini
Vibrio parahaemolyticus is a Gram-negative halophilic bacterium which is found largely in estuarine and coastal waters. The bacteria has been a main focus in gastro-intestinal infectio...
Campylobacter concisus is a Gram-negative bacterium that is associated with inflammatory bowel disease (IBD). Some C. concisus strains carry zonula occludens toxin (zot) gene which has...
Authors: Vikneswari Mahendran, Fang Liu, Stephen M. Riordan, Michael C. Grimm, Mark M. Tanaka and Li Zhang
Campylobacter species are recognized as the most common cause of foodborne bacterial gastroenteritis in humans. In this study nine Campylobacter strains isolated from chicken meat and ...
Authors: Tuan Ngoc Minh Nguyen, Helmut Hotzel, Hosny El-Adawy, Hanh Thi Tran, Minh Thi Hong Le, Herbert Tomaso, Heinrich Neubauer and Hafez Mohamed Hafez
Factors like ethnicity, diet and age of an individual have been hypothesized to play a role in determining the makeup of gut microbiome. In order to investigate the gut microbiome structure as well as the inte...
Authors: Deepak Yadav, Tarini Shankar Ghosh and Sharmila S. Mande
Salmonella enterica serovar Enteritidis (S. Enteritidis) is a human and animal pathogen that causes gastroenteritis characterized by inflammatory diarrhea and occasionally an invasive ...
Authors: Jacob R. Elder, Kim Lam Chiok, Narayan C. Paul, Gary Haldorson, Jean Guard and Devendra H. Shah
Macrobrachium rosenbergii is well-known as the giant freshwater prawn, and is a commercially significant source of seafood. Its production can be affected by various bacterial contaminati...
The non-shiga toxin-producing Escherichia coli (non-STEC) O157 is a pathogenic strain that cause diarrhea but does not cause hemolytic-uremic syndrome, or hemorrhagic colitis. Here, we present the 5-Mb draft geno...
Authors: Taesoo Kwon, Jung-Beom Kim, Young-Seok Bak, Young-Bin Yu, Ki Sung Kwon, Won Kim and Seung-Hak Cho
