A "cluster" of patients refers to the geographic proximity of unrelated patients with the same disease and suggests a common environmental cause for that disease. Clusters of patients with Crohn's disease have...
Microbiology is a relatively modern scientific discipline intended to objectively study microorganisms, including pathogens and nonpathogens. However, since its birth, this science has been negatively affected...
Johne's disease is chronic inflammation of the intestine caused by Mycobacterium avium subspecies paratuberculosis. Infection and disease are mainly in domestic livestock but can affect many species including pri...
Physiological stressors may alter susceptibility of the host intestinal epithelium to infection by enteric pathogens. In the current study, cytotoxic effect, adhesion and invasion of Salmonella enterica serovar T...
Potential biological roles of the Campylobacter jejuni genes cj0641, cj0774c and cj1663 were investigated. The proteins encoded by these genes showed sequence similarities to the phosphonate utilisation PhnH, K a...
Authors: Lauren E Hartley, Nadeem O Kaakoush, Justin L Ford, Victoria Korolik and George L Mendz
homB encodes a Helicobacter pylori outer membrane protein. This gene was previously associated with peptic ulcer disease (PUD) and was shown to induce activation of interleukin-8 secretion in vitro, as well as co...
Authors: Monica Oleastro, Rita Cordeiro, Yoshio Yamaoka, Dulciene Queiroz, Francis Mégraud, Lurdes Monteiro and Armelle Ménard
In the present study we demonstrate that the initial attachment of Listeria monocytogenes cells to plastic surfaces was significantly increased by growth in the presence of bile. Improved biofilm formation was co...
Anaerobic spirochaetes of the genus Brachyspira have long been known as important gut pathogens of pigs, but increasingly they are recognised as causing disease in birds and other animal species, including human ...
The induction of antigen-specific CD8+ T cell cytokine responses against an attenuated, oral recombinant Salmonella enterica serovar Typhimurium vaccine expressing a green fluorescent protein (GFP) model antigen ...
Authors: Nyasha Chin'ombe, William R Bourn, Anna-Lise Williamson and Enid G Shephard
Probiotic microorganisms are receiving increasing interest for use in the prevention, treatment, or dietary management of certain diseases, including antibiotic-associated diarrhea (AAD). Clostridium difficile is...
Authors: Pratik Banerjee, Glenn J Merkel and Arun K Bhunia
Small intestinal Clostridium difficile seems to be increasing in incidence. The spectrum of Clostridium difficile infection (CDI) has definitely expanded with small bowel involvement. They are more frequently rep...
Authors: Udayakumar Navaneethan and Ralph A Giannella
Chronic fatigue syndrome (CFS) is complex illness of unknown etiology. Among the broad range of symptoms, many patients report disturbances in the emotional realm, the most frequent of which is anxiety. Resear...
Authors: A Venket Rao, Alison C Bested, Tracey M Beaulne, Martin A Katzman, Christina Iorio, John M Berardi and Alan C Logan
The putative H. pylori pathogenicity-associated factor dupA has been associated with IL-8 induction in vitro, and duodenal ulcer (DU) and gastric cancer (GC) development in certain populations, but this associati...
Authors: Heather-Marie A Schmidt, Sönke Andres, Nadeem O Kaakoush, Lars Engstrand, Lena Eriksson, Khean-Lee Goh, Kwong Ming Fock, Ida Hilmi, Subbiah Dhamodaran, David Forman and Hazel Mitchell
Mycobacterium avium subspecies paratuberculosis (MAP) causes a chronic wasting diarrheal disease in ruminants called Johne's disease, that is evocative of human inflammatory bowel disease (IBD). Agents used to tr...
Authors: Robert J Greenstein, Liya Su, Robert H Whitlock and Sheldon T Brown
Intestinal infections and diarrhoeal diseases of humans are under-reported yet each account worldwide for more deaths than those from Tuberculosis. For external gut pathogens to do this they have to penetrate,...
Campylobacter enteritis represents a risk factor for the development of inflammatory bowel disease (IBD) via unknown mechanisms. As IBD patients exhibit inflammatory responses to their commensal intestinal microf...
Authors: Lisa D Kalischuk, G Douglas Inglis and Andre G Buret
