Articles

An oral recombinant Salmonella enterica serovar Typhimurium mutant elicits systemic antigen-specific CD8+ T cell cytokine responses in mice

The induction of antigen-specific CD8+ T cell cytokine responses against an attenuated, oral recombinant Salmonella enterica serovar Typhimurium vaccine expressing a green fluorescent protein (GFP) model antigen ...

Authors: Nyasha Chin'ombe, William R Bourn, Anna-Lise Williamson and Enid G Shephard

Lactobacillus delbrueckii ssp. bulgaricus B-30892 can inhibit cytotoxic effects and adhesion of pathogenic Clostridium difficile to Caco-2 cells

Probiotic microorganisms are receiving increasing interest for use in the prevention, treatment, or dietary management of certain diseases, including antibiotic-associated diarrhea (AAD). Clostridium difficile is...

Authors: Pratik Banerjee, Glenn J Merkel and Arun K Bhunia

Thinking beyond the colon-small bowel Involvement in clostridium difficile infection

Small intestinal Clostridium difficile seems to be increasing in incidence. The spectrum of Clostridium difficile infection (CDI) has definitely expanded with small bowel involvement. They are more frequently rep...

Authors: Udayakumar Navaneethan and Ralph A Giannella

A randomized, double-blind, placebo-controlled pilot study of a probiotic in emotional symptoms of chronic fatigue syndrome

Chronic fatigue syndrome (CFS) is complex illness of unknown etiology. Among the broad range of symptoms, many patients report disturbances in the emotional realm, the most frequent of which is anxiety. Resear...

Authors: A Venket Rao, Alison C Bested, Tracey M Beaulne, Martin A Katzman, Christina Iorio, John M Berardi and Alan C Logan

The prevalence of the duodenal ulcer promoting gene (dupA) in Helicobacter pylori isolates varies by ethnic group and is not universally associated with disease development: a case-control study

The putative H. pylori pathogenicity-associated factor dupA has been associated with IL-8 induction in vitro, and duodenal ulcer (DU) and gastric cancer (GC) development in certain populations, but this associati...

Authors: Heather-Marie A Schmidt, Sönke Andres, Nadeem O Kaakoush, Lars Engstrand, Lena Eriksson, Khean-Lee Goh, Kwong Ming Fock, Ida Hilmi, Subbiah Dhamodaran, David Forman and Hazel Mitchell

Monensin causes dose dependent inhibition of Mycobacterium avium subspecies paratuberculosis in radiometric culture

Mycobacterium avium subspecies paratuberculosis (MAP) causes a chronic wasting diarrheal disease in ruminants called Johne's disease, that is evocative of human inflammatory bowel disease (IBD). Agents used to tr...

Authors: Robert J Greenstein, Liya Su, Robert H Whitlock and Sheldon T Brown

Gut pathogens: invaders and turncoats in a complex cosmos

Intestinal infections and diarrhoeal diseases of humans are under-reported yet each account worldwide for more deaths than those from Tuberculosis. For external gut pathogens to do this they have to penetrate,...

Authors: John Hermon-Taylor

Campylobacter jejuni induces transcellular translocation of commensal bacteria via lipid rafts

Campylobacter enteritis represents a risk factor for the development of inflammatory bowel disease (IBD) via unknown mechanisms. As IBD patients exhibit inflammatory responses to their commensal intestinal microf...

Authors: Lisa D Kalischuk, G Douglas Inglis and Andre G Buret

Gut Pathogens: enteric health at the interface of changing microbiology

Authors: Niyaz Ahmed, Leonardo A Sechi, Francis Megraud and Seyed E Hasnain