Members of the genus Hafnia have been isolated from the feces of mammals, birds, reptiles, and fish, as well as from soil, water, sewage, and foods. Hafnia alvei is an opportunistic pathogen that has been implica...
Authors: Hye Seon Song, Joon Yong Kim, Yeon Bee Kim, Myeong Seon Jeong, Jisu Kang, Jin-Kyu Rhee, Joseph Kwon, Ju Suk Kim, Jong-Soon Choi, Hak-Jong Choi, Young-Do Nam and Seong Woon Roh
The serine protease HtrA is an important factor for regulating stress responses and protein quality control in bacteria. In recent studies, we have demonstrated that the gastric pathogen Helicobacter pylori can s...
Authors: Aileen Harrer, Manja Boehm, Steffen Backert and Nicole Tegtmeyer
Klebsiella pneumoniae (K. pneumoniae) is an opportunistic pathogen associated with community-acquired infections and nosocomial infections. From 2010 to 2015, K. pneumoniae testing was...
Authors: Bing Lu, Haijian Zhou, Xin Zhang, Mei Qu, Ying Huang and Quanyi Wang
Unrelated spore-forming bacteria share unique characteristics stemming from the presence of highly resistant endospores, leading to similar challenges in health and disease. These characteristics are related t...
Campylobacter is a well-known bacterial pathogen for triggering acute gastroenteritis in humans both in developed and developing countries. This organism is highly resistant to fluoroq...
Authors: Piyali Mukherjee, Shanta Dutta and Asish K. Mukhopadhyay
The pH of the human gastric mucosa varies around 2.5 so that only bacteria with strong acidic stress tolerance can colonize it. The ulcer causing Helicobacter pylori thrives in the gastric mucosa. We analyse the ...
Authors: Hilde S. Vollan, Tone Tannæs, Dominique A. Caugant, Gert Vriend and Geir Bukholm
Recent studies show that some Escherichia coli strains possessing a gene cluster named the pks island might have a causative role in the development of human colorectal cancer (CRC). In several reports from Europ...
Mycobacterium avium subspecies paratuberculosis (MAP) is the causative agent of Johne’s disease in ruminants and is associated with Crohn’s disease (CD) in humans, although the latter ...
Authors: Nicole Parrish, Aravinda Vadlamudi and Neil Goldberg
Campylobacter jejuni infections are of rising importance worldwide. Given that innate immune receptors including nucleotide-oligomerization-domain-2 (Nod2) are essentially involved in ...
Authors: Stefan Bereswill, Ursula Grundmann, Marie E. Alutis, André Fischer, Anja A. Kühl and Markus M. Heimesaat
Clostridium perfringens is an opportunistic human pathogen that causes necrotic enteritis, mild diarrhea, clostridial myonecrosis or gas gangrene, sepsis, etc. In this study, we aim to...
Authors: Yeon Bee Kim, Joon Yong Kim, Hye Seon Song, Changsu Lee, Joseph Kwon, Jisu Kang, Jin-Kyu Rhee, Myeong Seon Jeong, Young-Do Nam and Seong Woon Roh
Vibrio campbellii is widely distributed in the marine environment and is an important pathogen of aquatic organisms such as shrimp, fish, and mollusks. An isolate of V. campbellii carr...
Authors: Xuan Dong, Hailiang Wang, Peizhuo Zou, Jiayuan Chen, Zhen Liu, Xuepeng Wang and Jie Huang
Shiga toxin (Stx) producing Escherichia coli (E. coli) (STEC) is the most frequent cause of diarrhoea-positive haemolytic uraemic syndrome (D + HUS) in humans. In 2011, a huge outbreak with an STEC O104:H4 strain...
Authors: Bettina Wöchtl, Florian Gunzer, Wilhelm Gerner, Hagen Gasse, Michaela Koch, Zoltán Bagó, Martin Ganter, Herbert Weissenböck, Nora Dinhopl, Sina M. Coldewey, Alexandra von Altrock, Karl-Heinz Waldmann, Armin Saalmüller, Kurt Zimmermann, Jörg Steinmann, Jan Kehrmann…
Bacillus cereus is well known as a gastrointestinal pathogen that causes food-borne illness. In the present study, we sequenced the complete genome of B. cereus FORC_013 isolated from ...
Authors: Hyun-Jin Koo, Sojin Ahn, Han Young Chung, Suyeon Kim, Kwondo Kim, Sangryeol Ryu, Ju-Hoon Lee, Sang Ho Choi and Heebal Kim
There is a growing concern about the increase in human morbidity and mortality caused by foodborne pathogens. Antibiotics were and still are used as the first line of defense against these pathogens, but an in...
Authors: Moloko Gloria Mathipa and Mapitsi Silvester Thantsha
Coeliac disease is an autoimmune disorder resulting from an interaction between diet, genome and immunity. The treatment of CoeD is lifelong adherence to a gluten free diet, which is associated with clinical a...
Authors: Joanna Harnett, Stephen P. Myers and Margaret Rolfe
Bifidobacterium longum 105-A produces markedly high amounts of capsular polysaccharides (CPS) and exopolysaccharides (EPS) that should play distinct roles in bacterial–host interaction...
Authors: Amin Tahoun, Hisayoshi Masutani, Hanem El-Sharkawy, Trudi Gillespie, Ryo P. Honda, Kazuo Kuwata, Mizuho Inagaki, Tomio Yabe, Izumi Nomura and Tohru Suzuki
In 2007, a nationwide Salmonella Tennessee outbreak occurred via contaminated peanut butter. Here, we developed a single-nucleotide polymorphism (SNP)-typing method for S. Tennessee to determine the clonal subtyp...
Authors: Hee-Jin Dong, Seongbeom Cho, David Boxrud, Shelly Rankin, Francis Downe, Judith Lovchik, Jim Gibson, Matt Erdman and A. Mahdi Saeed
Ruminants serve as one of the most important reservoirs for pathogenic Escherichia coli. Infection with E. coli, a foodborne enteropathogen, can lead to asymptomatic infections that can cause life-threatening com...
Authors: Mujeeb Ur Rehman, Hui Zhang, Muhammad Kashif Iqbal, Khalid Mehmood, Shucheng Huang, Fazul Nabi, Houqiang Luo, Yanfang Lan and Jiakui Li
Rotavirus (RV) induces diarrhoea through a sequence of enterotoxic and cytotoxic effects. The former are NSP4-dependent, induce calcium-dependent chloride secretion and involve oxidative stress. Diosmectite (D...
Authors: Vittoria Buccigrossi, Carla Russo, Amedeo Guarino, Maiara Brusco de Freitas and Alfredo Guarino
As a primary source of Shiga-toxin-producing Escherichia coli (STEC) infection, cattle are often targeted to develop strategies for reducing STEC contamination. Monitoring the virulence potentials of STEC isolate...
Authors: Hee-Jin Dong, Soomin Lee, Woohyun Kim, Jae-Uk An, Junhyung Kim, Danil Kim and Seongbeom Cho
Helicobacter pylori infection is associated with risk for chronic gastritis (CG), gastric ulcer (GU), duodenal ulcer (DU), and gastric cancer (GC). The H. pylori Cag type IV secretion ...
Authors: Hirofumi Ogawa, Akira Iwamoto, Toshihito Tanahashi, Rina Okada, Koji Yamamoto, Shin Nishiumi, Masaru Yoshida and Takeshi Azuma
Enterococcus faecalis, generally considered as a saprophytic bowel commensal, has recently emerged as an important nosocomial pathogen causing severe urinary tract infections, surgical...
Authors: Kelly Biaggini, Valérie Borrel, Sabine Szunerits, Rabah Boukherroub, Awa N’Diaye, Arthur Zébré, Maryse Bonnin-Jusserand, Guillaume Duflos, Marc Feuilloley, Djamel Drider, Pierre Déchelotte and Nathalie Connil
The gut of human harbors diverse commensal microbiota performing an array of beneficial role for the hosts. In the present study, the major commensal gut bacteria isolated by culturing methods from 15 children...
Authors: Shirajum Monira, Syeda Antara Shabnam, Sk. Imran Ali, Abdus Sadique, Fatema-Tuz Johura, Kazi Zillur Rahman, Nur Haque Alam, Haruo Watanabe and Munirul Alam
The vacA, cagA and babA2 genotypes of Helicobacter pylori are associated with gastric pathology. The objectives were to determine the frequency of infection and distribution of the vacA, cagA and babA2 genotypes ...
Authors: Adolfo Román-Román, Dinorah Nashely Martínez-Carrillo, Josefina Atrisco-Morales, Julio César Azúcar-Heziquio, Abner Saúl Cuevas-Caballero, Carlos Alberto Castañón-Sánchez, Roxana Reyes-Ríos, Reyes Betancourt-Linares, Salomón Reyes-Navarrete, Iván Cruz-del Carmen, Margarita Camorlinga-Ponce, Enoc Mariano Cortés-Malagón and Gloria Fernández-Tilapa
The incidence of human Campylobacter jejuni infections is progressively increasing worldwide. Probiotic compounds might open up valuable tools to decrease pathogen burden and subsequent pro-inflammatory immune re...
Authors: Ira Ekmekciu, Ulrike Fiebiger, Kerstin Stingl, Stefan Bereswill and Markus M. Heimesaat
There are multiple etiologies responsible for infectious gastroenteritis causing acute diarrhea which are often under diagnosed. Also acute diarrhea is one of the major causes of morbidity and mortality among ...
Escherichia coli, the gastrointestinal commensal, is also known to cause ocular infections such as conjunctivitis, keratitis and endophthalmitis. These infections are normally resolved...
Helicobacter pylori, colonize in stomach of ~50% of the world population. cag pathogenicity Island of H. pylori is one of the important virulent factors that attributed to gastric infl...
Authors: Nillu Ghosh, Prachetash Ghosh, Kousik Kesh, Asish K. Mukhopadhyay and Snehasikta Swarnakar
“Dysbiosis” in the gut microbiome has been implicated in auto-immune diseases, in inflammatory diseases, in some cancers and mental disorders. The challenge is to unravel the cellular and molecular basis of dy...
One of the working mechanisms of probiotic bacteria is their ability to compete with pathogens. To define the probiotic properties of seven Lactic Acid Bacteria (LAB) strains, we tested them for survival in si...
Authors: Raffaella Campana, Saskia van Hemert and Wally Baffone
Probiotic bacteria can induce immune regulation or immune tolerance in patients with allergic diseases, but the underlying mechanisms are still unclear. There has been a growing interest in the use of benefici...
Authors: Juan Zhang, Hui Su, Qiuhong Li, Haixia Wu, Mengyun Liu, Jianqiong Huang, Minghua Zeng, Yuejie Zheng and Xin Sun
Riboflavin is the precursor of important redox cofactors such as flavin mononucleotide (FMN) and flavin adenine dinucleotide, required for several biological processes. Vibrio cholerae, a pathogenic bacterium res...
Authors: Ignacio Sepúlveda Cisternas, Alexia Torres, Andrés Fuentes Flores and Víctor Antonio García Angulo
Toll-like receptors (TLRs) are the major pattern recognition receptors that mediate sensing of a wide range of microorganisms. TLR2 forms heterodimers with either TLR1 or TLR6, broadening its ligand diversity...
Authors: Laura Choteau, Hélène Vancraeyneste, Didier Le Roy, Laurent Dubuquoy, Luiginia Romani, Thierry Jouault, Daniel Poulain, Boualem Sendid, Thierry Calandra, Thierry Roger and Samir Jawhara
Salmonella is one of major causes of foodborne outbreaks globally. This study was conducted to estimate the prevalence, typing and antibiotic susceptibilities of Salmonella enterica se...
Authors: Hanem El-Sharkawy, Amin Tahoun, Abd El-Galiel A. El-Gohary, Moshira El-Abasy, Fares El-Khayat, Trudi Gillespie, Yukio Kitade, Hafez M. Hafez, Heinrich Neubauer and Hosny El-Adawy
The Shiga toxin-producing Escherichia coli (STEC) O157 strain NCCP15739 and non-STEC O157 strain NCCP15738 were isolated from outbreaks in Korea. We characterized NCCP15739 and NCCP15738 by genome sequencing and ...
Necrotic enteritis (NE) is an economically important disease of poultry caused by certain Clostridium perfringens type A strains. The NetB toxin plays a critical role in the pathogenesis of NE. We previously demo...
Authors: Hongzhuan Zhou, Dion Lepp, Yanlong Pei, Mei Liu, Xianhua Yin, Rongcai Ma, John F. Prescott and Joshua Gong
The nucleotide-binding oligomerisaton protein 2 (NOD2) constitutes a pivotal sensor of bacterial muramyl dipeptide and assures expression of distinct antimicrobial peptides and mediators produced by enterocyte...
Authors: Stefan Bereswill, Ursula Grundmann, Marie E. Alutis, André Fischer and Markus M. Heimesaat
The rising incidence of multidrug resistant (MDR) Gram-negative bacteria including Pseudomonas aeruginosa has become a serious issue in prevention of its spread particularly among hospitalized patients. It is, ho...
Authors: Eliane von Klitzing, Ira Ekmekciu, Stefan Bereswill and Markus M. Heimesaat
Vibrio cholerae converts glucose into either acid or the neutral end product acetoin and its survival in carbohydrate enriched media is linked to the nature of the byproducts produced. It...
Authors: Chirantana Sengupta, Manjula Ekka, Saurabh Arora, Prashant D. Dhaware, Rukhsana Chowdhury and Saumya Raychaudhuri
Cronobacter sakazakii is an emerging opportunistic pathogen that is associated with rare but life-threatening cases of severe diseases: meningitis, necrotizing enterocolitis, and sepsi...
Authors: Seongok Kim, You-Tae Kim, Hyunjin Yoon, Ju-Hoon Lee and Sangryeol Ryu
Inflammatory bowel disease (IBD) is described as a relapsing condition with high morbidity and uncertain complex pathogenesis. The association of Mycobacterium avium ssp. paratuberculosis (MAP) with Crohn’s disea...
Authors: Samin Zamani, Mohammad Reza Zali, Hamid Asadzadeh Aghdaei, Leonardo Antonio Sechi, Magdalena Niegowska, Elisa Caggiu, Rouhollah Keshavarz, Nader Mosavari and Mohammad Mehdi Feizabadi
Identifying the connection among diet, the intestinal microbiome, and host health is currently an area of intensive research, but the potential of dietary fiber (DF) consumption to ameliorate intestinal infla...
Authors: Janelle A. Jiminez, Trina C. Uwiera, D. Wade Abbott, Richard R. E. Uwiera and G. Douglas Inglis
We evaluated the effects of the probiotic Escherichia coli Nissle 1917 (EcN) and the antibiotic Ciprofloxacin (Cipro) on mRNA expression of intestinal epithelial cells (IEC) in gnotobiotic (Gn) piglets colonized ...
Authors: Francine C. Paim, Stephanie N. Langel, David D. Fischer, Sukumar Kandasamy, Lulu Shao, Moyasar A. Alhamo, Huang-Chi Huang, Anand Kumar, Gireesh Rajashekara, Linda J. Saif and Anastasia N. Vlasova
Listeria monocytogenes is an important foodborne pathogen that causes considerable morbidity in humans with high mortality rates. In this study, we have sequenced the genomes and perfo...
Authors: Shu Yong Lim, Kien-Pong Yap and Kwai Lin Thong
Systemic lupus erythematosus (SLE) in patients from Spain is associated with intestinal dysbiosis. This study explores whether the alteration of the gut microbiome in SLE patients from China is consistent with...
Clostridium difficile (CD), a spore-forming and toxin-producing bacterium, is the main cause for antibiotic-associated diarrhea in the elderly. Here we investigated CD colonization in ...
Authors: Sophie Fehlbaum, Christophe Chassard, Sophie Annick Poeker, Muriel Derrien, Candice Fourmestraux and Christophe Lacroix
Enterococcus faecalis, the type strain of the genus Enterococcus, is not only a commensal bacterium in the gastrointestinal tract in vertebrates and invertebrates, but also causes seri...
Authors: Joon Yong Kim, Hye Seon Song, Yeon Bee Kim, Joseph Kwon, Jong-Soon Choi, Yong-Joon Cho, Byung-Yong Kim, Jin-Kyu Rhee, Jinjong Myoung, Young-Do Nam and Seong Woon Roh
Mouse infection studies have shown that interferon-γ (IFN-γ), a T helper 1 (Th1) cytokine, is required for the development of severe pathology induced by chronic Helicobacter infection. This finding is largely ba...
Authors: Michelle Chonwerawong, Patrick Avé, Michel Huerre and Richard L. Ferrero
More than 50 years after the discovery of antibiotics, bacterial infections have decreased substantially; however, antibiotics also may have negative effects such as increasing susceptibility to pathogens. An ...
Authors: Tadasu Iizumi, Takako Taniguchi, Wataru Yamazaki, Geraldine Vilmen, Alexander V. Alekseyenko, Zhan Gao, Guillermo I. Perez Perez and Martin J. Blaser
Foodborne illness can occur due to various pathogenic bacteria such as Staphylococcus aureus, Escherichia coli and Vibrio parahaemolyticus, and can cause severe gastroenteritis symptoms. In this study, we complet...
Authors: Sojin Ahn, Han Young Chung, Sooyeon Lim, Kwondo Kim, Suyeon Kim, Eun Jung Na, Kelsey Caetano-Anolles, Ju-Hoon Lee, Sangryeol Ryu, Sang Ho Choi and Heebal Kim
